Case Scenario

Mr Walker, aged 59 and weighing 100 kg, is found at home acting erratically. His clothing is drenched, the shower is running and his medicines are scattered everywhere. His Glasgow Coma Scale (GCS) score is fluctuating between 5 and 14 and he is agitated. The ambulance transports him to hospital.

Initial observations are: temperature 37.8°C, blood pressure (BP) 106/64 mmHg, heart rate 105 bpm, respiratory rate 16 breaths/minute, oxygen saturation 98%. Initial labs show white cell count 25×109/L, creatinine 160 micromol/L (baseline 60). Urgent blood cultures have been sent, and 2 L of 0.9% sodium chloride has been administered intravenously. His BP is now 98/67 mmHg. A central line is inserted and noradrenaline infusion commenced.

Learning Objectives

After reading this article, pharmacists should be able to:

  • Describe the symptoms of sepsis
  • Describe the metabolic changes caused by sepsis
  • Discuss first-line management for sepsis
  • Explain how pharmacists can help to manage patients with sepsis.

Competency

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