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AUSTRALIAN PHARMACIST
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    • td_module_mega_menu Object
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                  [ID] => 29310
                  [post_author] => 3410
                  [post_date] => 2025-05-07 14:26:37
                  [post_date_gmt] => 2025-05-07 04:26:37
                  [post_content] => Merging CAL 18 and CAL I removes duplication and confusion, helping patients receive clearer, more actionable dietary advice.
      
      Australian Pharmacist explores what pharmacists and patients need to know.
      
      What’s changing?
      
      Cautionary advisory label (CAL) 18 and CAL I currently provide dietary advice for specific medicines:
      
      [caption id="attachment_29312" align="aligncenter" width="151"] CAL 18[/caption]
      
      [caption id="attachment_29311" align="aligncenter" width="152"] CAL I[/caption]
      

      Instead of having two labels that relate to avoiding certain foods and juices (CAL 18 and CAL I), there will now be one – an updated CAL 18.

      [caption id="attachment_29313" align="aligncenter" width="189"] Revised CAL 18[/caption]

      What’s the rationale?

      Currently, CAL 18 only warns about grapefruit due to its effect on the bioavailability of certain medicines through the selective inhibition of cytochrome P450 3A4 isoenzymes. But the product information (PI) for new medicines that are substrates for CYP3A4 increasingly mention other fruits (beyond just grapefruit) as interacting with medicines via inhibition of CYP3A4. This includes seville oranges, pomelo, star fruit, bitter melon and pomegranate.  As it stands, the wording of CAL 18 is not broad enough to cover these scenarios. CAL I is currently used to advise patients about fruits and juices that interact with medicines through mechanisms other than inhibition of CYP3A4.  For example, food and drink interactions with non-selective monoamine oxidase inhibitors (MAOIs) and interactions between medicines and fruit juices through mechanisms other than CYP3A4 inhibition (e.g. fexofenadine, which has been found to interact with orange and apple juice).  However, there have been reports of confusion associated with ‘I’ appearing very similar to ‘1’ in the CAL recommendation table. There are also not many medicines CAL I is relevant to at present, so it therefore has limited applicability.  The revised CAL 18, now reading ‘Certain foods and fruit juices should be avoided while being treated with this medicine’, will now cover:
      • interactions with all CYP3A4-inhibiting fruits (for example, grapefruit, Seville orange, pomelo, pomegranate, star fruit) 
      • any newly identified food and juice interactions with medicines – even those that don’t occur by CYP3A4 (e.g. apple and orange juice); and
      • other food and drink interactions with medicines (e.g. foods and drinks rich in tyramine with MAOIs).

      How should pharmacists respond when patients ask which foods and fruit juices should be avoided?

      For those fruits that can inhibit CYP3A4 (e.g. grapefruit, Seville orange, pomelo, star fruit, bitter melon and pomegranate), this can lead to higher drug levels and potential toxicity of relevant CYP3A4 substrates. Pharmacists should advise patients that these fruits should be avoided in any form (e.g. fruit or juice) with these medicines as there is no recommendation on the quantity that can be safely consumed. Beyond CYP3A4 substrates, it becomes more nuanced. For example, atenolol and fexofenadine aren’t metabolised by CYP3A4, yet both can have reduced bioavailability when taken with apple or orange juice – so patients taking these medicines should be advised to avoid these juices. When dispensing MAOIs, pharmacists should counsel patients to avoid tyramine-rich foods such as aged cheeses, cured meats, fermented products, yeast extract products and beer. Other certain foods and drinks must be consumed only in small amounts. MAOIs block the enzyme that normally breaks down tyramine, causing it to accumulate in the bloodstream, which can lead to a hypertensive crisis. Pharmacists should provide an MAOI card to patients, see APF Digital – Counselling advice for monoamine oxidase inhibitors.  It is important that pharmacists check a medicines’ approved PI to confirm the specific foods, fruits and juices that patients should avoid. Appropriate drug interaction resources (e.g. Stockley’s Drug Interactions) should also be used where needed when providing medicine-specific advice.

      When is the change happening?

      The CAL explanatory notes were updated in APF Digital today (7 May 2025). Pharmacists should familiarise themselves with the revised explanatory notes for CAL 18 in the digital Australian Pharmaceutical Formulary and Handbook.

      When will dispensing software be updated with the revised CALs?

      Pharmacists are advised to talk to their dispensing software provider, who can advise when these changes will be implemented.

      When will the new labels arrive?

      It is anticipated printers will commence printing of the new labels during their next print run. Until then, pharmacists should use the existing CAL 18 and CAL I – ensuring patients are equipped with the updated advice, available now in APF Digital which always contains the latest updates. [post_title] => Goodbye CAL I, hello expanded CAL 18 [post_excerpt] => Merging CAL 18 and CAL I removes duplication and confusion, helping patients receive clearer, more actionable dietary advice. [post_status] => publish [comment_status] => open [ping_status] => open [post_password] => [post_name] => goodbye-cal-i-hello-expanded-cal-18 [to_ping] => [pinged] => [post_modified] => 2025-05-07 17:21:44 [post_modified_gmt] => 2025-05-07 07:21:44 [post_content_filtered] => [post_parent] => 0 [guid] => https://www.australianpharmacist.com.au/?p=29310 [menu_order] => 0 [post_type] => post [post_mime_type] => [comment_count] => 0 [filter] => raw ) [title_attribute] => Goodbye CAL I, hello expanded CAL 18 [title] => Goodbye CAL I, hello expanded CAL 18 [href] => https://www.australianpharmacist.com.au/goodbye-cal-i-hello-expanded-cal-18/ [module_atts:td_module:private] => Array ( ) [td_review:protected] => Array ( ) [is_review:protected] => [post_thumb_id:protected] => 29315 [authorType] => )

      Goodbye CAL I, hello expanded CAL 18

      measles
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                  [ID] => 29295
                  [post_author] => 3410
                  [post_date] => 2025-05-05 14:47:58
                  [post_date_gmt] => 2025-05-05 04:47:58
                  [post_content] => With measles cases climbing across Australia and pharmacies increasingly listed as exposure sites, community pharmacists must be prepared.
      
      
      Earlier this year, a patient who had just returned from Vietnam walked into Advantage Chesterville Pharmacy in Melbourne with a script for antibiotics.
      
      ‘She was wearing a face mask, and when I spoke to her she just said that she had a cough but she wasn't sure what the cough was from,’ said community pharmacist Minh Ngo MPS, who was on duty when the patient came through.
      
      Some time later, the pharmacy received word that the patient was infected with measles.
      
      ‘She either informed the hospital or the GP, but we just got a call from the [Victorian] Department of Health to notify us that we were an exposure case,’ she said.
      
      With measles spreading around Australia at an unprecedented rate, this is a position many pharmacists may soon find themselves in.
      
      Victoria is in the midst of its worst measles outbreak in a decade, with 25 cases recorded so far this year. New South Wales and Western Australia are not far behind, with 21 and 18 cases reported respectively.
      
      Healthcare settings such as pharmacies have been increasingly listed as exposure sites as people seek treatment for the highly infectious and virulent disease.
      
      Australian Pharmacist explores the steps pharmacists should take when confronted with this predicament.
      

      Patient contact tracing

      When a healthcare setting such as a pharmacy becomes a measles exposure site, it is responsible for contact tracing. ‘We had to inform every patient who was in the [pharmacy] at that time that we were informed that the exposure might have happened,’ Ms Ngo said.  This includes asking patients if they have any symptoms. Early symptoms of measles, before the rash appears, include:
      • fever 
      • tiredness 
      • cough 
      • runny nose
      • sore red eyes 
      • malaise.
      ‘We had to inform every patient who was in the [pharmacy] at that time that we were informed that the exposure might have happened.' MINH NGO MPS  

      Post-exposure testing and prophylaxis

      All symptomatic patients who were exposed to measles need to follow specific protocols.  ‘We told them that if they have any symptoms, if they develop any cough or if they have any concerns then go and get tested,’ Ms Ngo said.  Patients who have attended a known exposure site should be offered the Measles, Mumps, and Rubella vaccine within 72 hours of measles exposure to avert infection. In those who are unvaccinated or partially vaccinated, particularly young infants, pregnant people,, or immunocompromised patients – human immunoglobulin (NHIG) administered within six days of exposure may be appropriate. Pharmacists should advise patients with suspected measles to call ahead before visiting their healthcare provider for a PCR test and wear a mask upon leaving home. Suspected cases must remain isolated at home until laboratory testing confirms or excludes measles, avoiding work, school and any public venues. A notification must be made to the relevant department of health when symptoms are present via the patients' local public health unit.

      Important staff protocols

      Fortunately, there were only two members of staff on at the pharmacy including Ms Ngo at the time of the exposure, and neither was infected with measles.
      Local PHUs will identify any staff who may have been exposed to a measles case and assess their immunity status, said a spokesperson from the federal Department of Health and Aged Care. ‘Depending on their vaccination history, some staff members may need to be monitored or excluded from work during the infectious period to minimise the risk of further transmission – this could be for a period up to 18 days,’ the spokesperson said. ‘Post-exposure prophylaxis may be required and will be organised by the local PHU.’ With the number of cases currently floating around, pharmacists should ensure that staff are up to date with their vaccinations in advance All adults born between 1966 and 1992 and who do not have documented evidence of vaccination are eligible for a catch-up vaccine to ensure maximum protection against measles, with the two-dose schedule of the MMR vaccine only being introduced in Australia in 1992. https://twitter.com/VicGovDH/status/1916756251293409486 Should a patient present with a fever and rash, they should be moved out of communal waiting areas and into a dedicated space. If measles is suspected, the patient should be given a disposable, well-sealed mask. [post_title] => Responding to a measles exposure in your pharmacy [post_excerpt] => With measles cases climbing across Australia and pharmacies increasingly listed as exposure sites, community pharmacists must be prepared. [post_status] => publish [comment_status] => open [ping_status] => open [post_password] => [post_name] => responding-to-a-measles-exposure-in-your-pharmacy [to_ping] => [pinged] => [post_modified] => 2025-05-06 10:32:42 [post_modified_gmt] => 2025-05-06 00:32:42 [post_content_filtered] => [post_parent] => 0 [guid] => https://www.australianpharmacist.com.au/?p=29295 [menu_order] => 0 [post_type] => post [post_mime_type] => [comment_count] => 0 [filter] => raw ) [title_attribute] => Responding to a measles exposure in your pharmacy [title] => Responding to a measles exposure in your pharmacy [href] => https://www.australianpharmacist.com.au/responding-to-a-measles-exposure-in-your-pharmacy/ [module_atts:td_module:private] => Array ( ) [td_review:protected] => Array ( ) [is_review:protected] => [post_thumb_id:protected] => 29305 [authorType] => )

      Responding to a measles exposure in your pharmacy

      esketamine
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                  [ID] => 29255
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                  [post_date] => 2025-04-30 11:57:51
                  [post_date_gmt] => 2025-04-30 01:57:51
                  [post_content] => From 1 May, Spravato (esketamine) will be subsidised under the Pharmaceutical Benefits Scheme (PBS) for adults with treatment-resistant depression, intended for use alongside a newly initiated oral antidepressant.
      
      Up to 30,000 Australians are anticipated to access esketamine via the PBS, paying only $7.70 per dose with a pensioner or concession card, or $31.60 per dose for general patients.
      
      [caption id="attachment_29259" align="alignright" width="233"] Professor Malcolm Hopwood[/caption]
      
      Australian Pharmacist spoke with Professor Malcolm Hopwood, Ramsay Health Care Professor of Psychiatry at the University of Melbourne, about the treatment process and how pharmacists will be involved.
      

      How effective is esketamine in managing treatment resistant depression?

      The largest clinical trials on esketamine efficacy found that about 50% of patients who had not responded to two or three antidepressants did respond to esketamine, Prof Hopwood said. ‘If you compare that to trialing one of the usual medicines, the response rate for the third or fourth [medicine] is probably only about 15%,’ he said. ‘So it’s quite a jump up in terms of response rate.’

      Who is eligible to be prescribed esketamine nasal spray?

      Those diagnosed with treatment-resistant depression, defined as major depressive disorder that has not responded sufficiently to at least two different antidepressants, each administered at an adequate dose and duration, for the treatment of the current moderate to severe depressive episode.

      Who is not a good candidate for this treatment?

      Esketamine is currently not indicated for bipolar depression. And caution should be taken for patients with psychotic depression, Prof Hopwood said.  ‘[This is] because ketamine, when used in much higher doses, has psychogenic potential,’ Prof Hopwood said. There is also a precautionary note in the product information around patients with marked hepatic or renal impairment. ‘In terms of drug-drug interactions, it should not be used together with an irreversible monoamine oxidase inhibitor, which these days is only Parnate,’ he said. ‘While not widely used now, it's an important interaction to be aware of.’

      What’s the duration of therapy?

      Esketamine is initially administered twice weekly for the first 4 weeks, Prof Hopwood said. ‘By the end of that 4-week period, we've usually got a sense whether you're a responder or not.’ Treatment usually stops in non-responders, with responders moving to a once-weekly treatment regimen. ‘Eventually, fortnightly treatment for a 6-month maintenance period is what we recommend,’ Prof Hopwood said.

      Is re-treatment recommended?

      Given that depression is a highly recurrent condition, it is likely some patients will relapse post treatment. And re-treatment with esketamine could prove beneficial, Prof Hopwood said. ‘There is some data about re-treatment …  [with] evidence showing that responders do seem to have a good response rate the second time around,’ he said. ‘That will be permitted under this funding scheme.’

      How is esketamine supplied?

      Patients cannot be in possession of the spray until they are in the clinic for administration under supervision, Prof Hopwood said.  ‘Esketamine needs to be administered in an approved treatment center that involves close supervision for side effects such as dissociation and hypertension,’ he said.  Appropriate pharmacist handling of a Schedule 8 medicine is also required. ‘In our facility, we are fortunate to have an on-site pharmacist who dispenses [the medicine] to a nurse, and then the patient self-administers,’ Prof Hopwood said.  ‘But the patient neither brings the medicine to the clinic or takes it away. The intent … is to reduce the risk of diversion.’ Facilities that do not have an on-site pharmacist must establish and demonstrate a connection with a local community pharmacy to qualify as an approved treatment centre.

      Is talk therapy involved in the session?

      Treatment with esketamine does not involve psychotherapy. However, there is a small body of research currently looking at ketamine-facilitated psychotherapy, Prof Hopwood said. ‘We still don't know whether that offers additional benefit for many patients, [but] if esketamine proves an effective treatment for their depression, they may be able to utilise psychotherapy much more effectively – which they might not be able to do when severely depressed.’

      What are the estimated costs of esketamine sessions?

      The estimated cost is $300–$350 per treatment session, Prof Hopwood said. In most clinics, the doctor will see the patient on treatment occasions, but less so as treatment becomes established. ‘If the doctor does visit before the treatment is administered, then they can claim through Medicare as per usual,’ he said. ‘But the nursing and pharmacy [costs] will not be covered.’

      Are patients supposed to disassociate when they take esketamine?

      Dissociation with treatment is frequent, albeit mild and transient for most patients, Prof Hopwood said. ‘For up to half an hour they [may] feel a little dreamy and not unpleasant,’ he said.  Some evidence suggests that mild dissociative effects may be required for the drug to be effective in the treatment of depression, although this is not definitive, Prof Hopwood said. ‘We monitor patients during that time and keep them safe,’ he said. ‘Most of them simply want to lie there and listen to music or just bliss out for a short period of time.’  While there is no reversal agent for esketamine, any periods of distress are typically short lived. ‘We've had a very small number of patients distressed, consistent with the trials,’ Prof Hopwood said. ‘And they've generally responded to quite simple reassurance.’ Patients’ blood pressure is also monitored ‘It's rarely severe enough that intervention is required, but there can be a transient increase, as we've known from the use of ketamine as an anaesthetic,’ he said.

      Where should pharmacists refer interested patients?

      GPs are an important resource for knowing where the available treatment centers are, Prof Hopwood said.  ‘There is a list of those available, and I predict that number may increase over time now that esketamine is funded.’ There are high levels of patient interest in esketamine and psychedelics, Prof Hopwood said. ‘So it's important they receive accurate, quality information that includes realistic expectations about the likelihood of treatment response and what's involved,’ he said. ‘And pharmacists are very well placed to provide that kind of information.’

      What is preferable: esketamine or psychedelics?

      Since 1 July 2023, patients with treatment-resistant depression have legally been allowed to receive treatment with psilocybin and MDMA, under specific conditions.   There is a degree of overlap between the patient populations considered suitable for ketamine and psychedelic therapy, Prof Hopwood said. ‘Most of the current guidance, including from The Royal Australian and New Zealand College of Psychiatrists, would say that psychedelic therapy is still more at a research level,’ he said.  ‘Whereas, esketamine, reflected in the funding, has reached a higher level of evidence at this point.  ‘So I would certainly see it as coming before psychedelic therapy in any hierarchy.’ To find out more about the use of psilocybin for treatment-resistant depression, read Australian Pharmacist's CPD article on the therapeutic potential of psychedelics. [post_title] => PBS-backed esketamine rolls out for depression with S8 controls [post_excerpt] => Esketamine will soon be funded for treatment-resistant depression, requiring pharmacists to adhere to strict supply and handling conditions. [post_status] => publish [comment_status] => open [ping_status] => open [post_password] => [post_name] => pbs-backed-esketamine-rolls-out-for-depression-with-s8-controls [to_ping] => [pinged] => [post_modified] => 2025-04-30 15:17:32 [post_modified_gmt] => 2025-04-30 05:17:32 [post_content_filtered] => [post_parent] => 0 [guid] => https://www.australianpharmacist.com.au/?p=29255 [menu_order] => 0 [post_type] => post [post_mime_type] => [comment_count] => 0 [filter] => raw ) [title_attribute] => PBS-backed esketamine rolls out for depression with S8 controls [title] => PBS-backed esketamine rolls out for depression with S8 controls [href] => https://www.australianpharmacist.com.au/pbs-backed-esketamine-rolls-out-for-depression-with-s8-controls/ [module_atts:td_module:private] => Array ( ) [td_review:protected] => Array ( ) [is_review:protected] => [post_thumb_id:protected] => 29258 [authorType] => )

      PBS-backed esketamine rolls out for depression with S8 controls

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                  [post_date] => 2025-04-30 11:38:14
                  [post_date_gmt] => 2025-04-30 01:38:14
                  [post_content] => 

      Rosa is a 35-year-old professional struggling with persistent sleep disturbances. Despite maintaining a consistent sleep routine, exercising regularly, and avoiding heavy meals before bedtime, she found herself regularly waking during the night.

      The consultation

      [caption id="attachment_27686" align="alignright" width="300"]allergic rhinitis This article is sponsored by Kenvue.[/caption]

      Before providing Rosa a sleep aid such as melatonin supplements, you ask a series of questions to identify potential contributing factors for her condition and to determine if a sleep aid is the best treatment option.

      Key questions to ask

      Medical history:

      • Do you have a history of allergies or asthma?
      • Does anyone in your family have allergies or asthma?

      Duration of symptoms:

      • How long have you noticed symptoms?

      Symptom pattern:

      • Are the sleep disturbances worse at specific times of the year?

      Nasal symptoms:

      • Do you experience nasal congestion or breathing difficulties at night?
      • Have you noticed an increase in sneezing or runny nose lately?
      • Have you noticed any postnasal drip or coughing during the night?

      Sensory Irritation:

      • Do you experience any itching in your nose, eyes or throat?
      • Do your sleep problems coincide with other symptoms such as headaches or sinus pressure?

      Environmental factors:

      • Have there been any recent changes in your living environment that could be contributing to your symptoms?
      • Have you recently introduced new furniture, carpets or other items into your home that might be contributing to your symptoms?
      • Do you have pets in your home? If so, do you notice any worsening of symptoms when they are nearby?
      • Have you noticed any improvement in your sleep when you’re away from your usual environment?

      Timing of symptoms:

      • Are your symptoms worse in the morning or at night?

      Current approaches:

      • How have you been trying to improve your sleep?
      • Have you tried any allergy avoidance strategies such as using air purifiers or keeping pets out of the bedroom?
      • Do you use nasal sprays or other medications for congestion? If so, how often?

      Current medical status and medications:

      • Do you have any other health conditions?
      • Do you currently take any medication?

      The diagnosis

      Rosa reveals that when she wakes, she frequently has a blocked nose and itchy eyes, and she sneezes a lot in the evening before bed. She has suffered from very mild hayfever before but never at this time of year.

      You suspect allergic rhinitis as the root cause. Rosa was surprised. Like many, she had dismissed her nasal congestion as a minor annoyance rather than a significant factor affecting her rest. She didn’t even think one could get hayfever in winter.

      The treatment plan

      You recommend a treatment plan to tackle the root cause of Rosa’s sleep disturbances. With proper treatment, she can manage her symptoms and improve sleep quality. Alongside managing environmental exposure you can recommend an antihistamine like:

      Zyrtec Rapid Acting Allergy Antihistamine and Hayfever Tablets

      Dosage: One tablet daily offers 24-hour protection.

      You can also recommend Rhinocort nasal spray to be used when symptoms become acute.1

      The outcome: restful nights and restored energy

      Within days of following the treatment plan, Rosa noticed a remarkable improvement. Her congestion eased, she wasn’t waking up anymore, and she finally felt refreshed and energised throughout the day.

      By looking beyond the immediate request for sleep aids, the pharmacist was able to identify the true cause of Rosa’s problem and offer a more effective, long-term solution.

      Allergic rhinitis (AR) and sleep disruptions

      Allergic rhinitis (AR), commonly known as hayfever, affects around 19% of Australians.2 Chronic nasalcongestion and other symptoms of allergic rhinitis can significantly impact sleep quality.3 This often results in daytime fatigue, decreased productivity, and impaired cognitive function. Patients may not realise that their persistent tiredness or difficulty concentrating stems from untreated allergies. Zyrtec works fast for hayfever relief and stays strong, day after day offering 24-hour relief from multiple symptoms.

      Zyrtec works fast for hay fever relief and stays strong, day after day.4

      If your patient is struggling with unexplained sleep disturbances, allergies could be the hidden cause.

      With the right management you can help them to reclaim restful sleep and feel their best every day.

      References

      1. Approach to management of allergic rhinitis, [2020; amended July 2024]. In: Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited.
      2. Definition and causes of allergic rhinitis, [2020; amended July 2024]. In: Therapeutic Guidelines.Melbourne: Therapeutic Guidelines Limited.
      3. Wise SK, Damask C, Roland LT, et al. International consensus statement on allergy and rhinology: Allergic rhinitis.
      4. Urdaneta E, et al. Ann Allergy Asthma Immunol 2010;105(5):A121. (Sponsored by Zyrtec.)

      [post_title] => Allergic rhinitis and sleep deprivation: What’s going undetected? [post_excerpt] => Allergic rhinitis (AR), commonly known as hayfever, affects around 19% of Australians. This case study explores how it impacts sleep quality. [post_status] => publish [comment_status] => open [ping_status] => open [post_password] => [post_name] => allergic-rhinitis-and-sleep-deprivation [to_ping] => [pinged] => [post_modified] => 2025-05-05 12:50:52 [post_modified_gmt] => 2025-05-05 02:50:52 [post_content_filtered] => [post_parent] => 0 [guid] => https://www.australianpharmacist.com.au/?p=29210 [menu_order] => 0 [post_type] => post [post_mime_type] => [comment_count] => 0 [filter] => raw ) [title_attribute] => Allergic rhinitis and sleep deprivation: What’s going undetected? [title] => Allergic rhinitis and sleep deprivation: What’s going undetected? [href] => https://www.australianpharmacist.com.au/allergic-rhinitis-and-sleep-deprivation/ [module_atts:td_module:private] => Array ( ) [td_review:protected] => Array ( ) [is_review:protected] => [post_thumb_id:protected] => 29273 [authorType] => )

      Allergic rhinitis and sleep deprivation: What’s going undetected?

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                  [post_date] => 2025-04-22 11:19:25
                  [post_date_gmt] => 2025-04-22 01:19:25
                  [post_content] => 

      Aside from administering medicines by injection, Queensland-based community pharmacist Fiona Watson MPS loves tearing up a Latin dance floor.

      Tell us about your pharmacy career.

      I had a varied early career, moving to North Queensland for a year shortly after I graduated as well as locuming around Australia for a while.

      This gave me a great introduction to community pharmacy and a lot of different experiences – both good and bad. When locuming, you develop a clear idea of the factors that contribute to a well-run pharmacy.

      I then moved to the United Kingdom where I completed a Certificate in Clinical Pharmacy. You can tell how old I am because I was one of the last pharmacists able to register in the UK with only a month under supervision.

      I was a ‘rotational resident pharmacist’, living on-site at the hospital. I covered renal, gastro, cardiology, oncology, aged care, palliative care and surgery wards.

      We worked on call overnight, and could get called upon to help with all sorts of different situations – one of the most interesting being calculating the correct dose for the antidote to antifreeze.

      More recently, I was very fortunate to be given the opportunity to go into partnership with my mum and sister, both pharmacists, as the managing partner at Redland Bay Wholelife Pharmacy and Healthfoods.

      What medicines do you administer by injection?

      About 10 years ago, I became a trained vaccinator administering thousands of vaccines during the COVID-19 pandemic.

      When Queensland allowed pharmacists to expand the range of medicines they could administer, I completed the Medication Administration course, as I believe this is an essential skill for pharmacists to have.

      So many new medications are injectable, and for some patients self-administration just isn’t an option. We were one of the first pharmacies in our area to offer long-acting injectable buprenorphine services, which can be a life-changing option for patients.

      Tell us about your administering injections beyond vaccines.

      The majority of pharmacists I work with at Redland Bay are trained vaccinators and have completed medicines administration courses. When we come across a new medication that requires administration by injection we collate the available information from the manufacturer and ensure everyone has read it. Many companies, such as Novartis with inclisiran (Leqvio), have reps who are happy to provide additional training.

      Once you are comfortable with subcutaneous injections, it’s a matter of familiarising yourself with the different types of devices available. It seemed a logical step for us to provide this service. We have great consult room facilities and it brings variety to our role.

      What role do you see pharmacists playing in cardiovascular care in future?

      The sky is the limit. We’re on the cusp of a fundamental change in the way Australians receive health care and I hope to see pharmacists embrace the opportunities this will bring.

      There’s a workforce crisis and an ageing population, so we need to become more efficient and accessible. If you think about how much the role of a nurse practitioner has changed in the last 10–15 years, you can see where pharmacists have even greater potential. A patient with a diagnosis of heart failure should be able to be titrated to optimum therapy by a pharmacist in a community pharmacy. A patient should have their HbA1c or lipids checked in the pharmacy, with appropriate therapy initiated or adjusted. We should also be actively involved in screening and chronic disease management.

      Pharmacy is an incredibly rewarding and enjoyable career, and now is an especially exciting time to be a pharmacist. There is just so much opportunity. 

      Day in the life of Fiona Watson MPS, Community pharmacist at Redland Bay Wholelife Pharmacy, QLD.

      5.00am

      Hit the gym

      I get up and do a HIIT or Muay Thai class most mornings for positive effects on my mental health. Passionate about preventative health care, I see the long-term effects of patients’ lifestyle choices every day.

      8.00am

      Open the pharmacy Every day is different. At least two pharmacists are rostered on, ensuring we give each patient the time they need while providing a wide range of different services.

      9.00am

      Vaccination service

      Embarking on a cruise in 2 months, a couple in their 60s asks about  COVID-19 vaccines. More than 12 months since their last vaccine they are  happy to be vaccinated on the spot. Not wanting more than one vaccine at a time, we book them in for a follow-up appointment in a month for the shingles vaccination.

      10.00am

      Collaborative care

      A local GP phones about a recently discharged mutual patient who’s not coping well on his new medicines. We spend some time with the patient doing a medicine review and setting up his profile for a dose administration aid.

      1.00pm

      Lunchtime

      It’s important that all staff, especially pharmacists, prioritise their breaks. We all need a little downtime to reset and refresh.

      1.30pm

      Medicines injection

      A regular patient comes in for her second dose of inclisiran (Leqvio) after I administered her first 3 months ago. She is happy with the more convenient option than visiting her GP.

      3.00pm

      Infection control

      In a call from our pharmacy car park, we learn a patient has tested positive for COVID-19 and has an e-script. We dispense and counsel over the phone and then deliver out to their car (with appropriate precautions).

      6.30pm

      OCP continuance

      A stressed young woman, with a 2-week wait for a GP appointment, has run out of her pill. She is relieved when seen by a colleague who prescribes Estelle under the Queensland Hormonal Contraceptive Pilot. I dispense it.

      [post_title] => Injectable medication administration an essential skill [post_excerpt] => Aside from administering medicines by injection, Queensland-based community pharmacist Fiona Watson MPS loves tearing up a Latin dance floor. [post_status] => publish [comment_status] => open [ping_status] => open [post_password] => [post_name] => injectable-medication-administration-an-essential-skill [to_ping] => [pinged] => [post_modified] => 2025-04-30 11:28:21 [post_modified_gmt] => 2025-04-30 01:28:21 [post_content_filtered] => [post_parent] => 0 [guid] => https://www.australianpharmacist.com.au/?p=29196 [menu_order] => 0 [post_type] => post [post_mime_type] => [comment_count] => 0 [filter] => raw ) [title_attribute] => Injectable medication administration an essential skill [title] => Injectable medication administration an essential skill [href] => https://www.australianpharmacist.com.au/injectable-medication-administration-an-essential-skill/ [module_atts:td_module:private] => Array ( ) [td_review:protected] => Array ( ) [is_review:protected] => [post_thumb_id:protected] => 29197 [authorType] => )

      Injectable medication administration an essential skill

  • Clinical
    • td_module_mega_menu Object
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          [post] => WP_Post Object
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                  [ID] => 29310
                  [post_author] => 3410
                  [post_date] => 2025-05-07 14:26:37
                  [post_date_gmt] => 2025-05-07 04:26:37
                  [post_content] => Merging CAL 18 and CAL I removes duplication and confusion, helping patients receive clearer, more actionable dietary advice.
      
      Australian Pharmacist explores what pharmacists and patients need to know.
      
      What’s changing?
      
      Cautionary advisory label (CAL) 18 and CAL I currently provide dietary advice for specific medicines:
      
      [caption id="attachment_29312" align="aligncenter" width="151"] CAL 18[/caption]
      
      [caption id="attachment_29311" align="aligncenter" width="152"] CAL I[/caption]
      

      Instead of having two labels that relate to avoiding certain foods and juices (CAL 18 and CAL I), there will now be one – an updated CAL 18.

      [caption id="attachment_29313" align="aligncenter" width="189"] Revised CAL 18[/caption]

      What’s the rationale?

      Currently, CAL 18 only warns about grapefruit due to its effect on the bioavailability of certain medicines through the selective inhibition of cytochrome P450 3A4 isoenzymes. But the product information (PI) for new medicines that are substrates for CYP3A4 increasingly mention other fruits (beyond just grapefruit) as interacting with medicines via inhibition of CYP3A4. This includes seville oranges, pomelo, star fruit, bitter melon and pomegranate.  As it stands, the wording of CAL 18 is not broad enough to cover these scenarios. CAL I is currently used to advise patients about fruits and juices that interact with medicines through mechanisms other than inhibition of CYP3A4.  For example, food and drink interactions with non-selective monoamine oxidase inhibitors (MAOIs) and interactions between medicines and fruit juices through mechanisms other than CYP3A4 inhibition (e.g. fexofenadine, which has been found to interact with orange and apple juice).  However, there have been reports of confusion associated with ‘I’ appearing very similar to ‘1’ in the CAL recommendation table. There are also not many medicines CAL I is relevant to at present, so it therefore has limited applicability.  The revised CAL 18, now reading ‘Certain foods and fruit juices should be avoided while being treated with this medicine’, will now cover:
      • interactions with all CYP3A4-inhibiting fruits (for example, grapefruit, Seville orange, pomelo, pomegranate, star fruit) 
      • any newly identified food and juice interactions with medicines – even those that don’t occur by CYP3A4 (e.g. apple and orange juice); and
      • other food and drink interactions with medicines (e.g. foods and drinks rich in tyramine with MAOIs).

      How should pharmacists respond when patients ask which foods and fruit juices should be avoided?

      For those fruits that can inhibit CYP3A4 (e.g. grapefruit, Seville orange, pomelo, star fruit, bitter melon and pomegranate), this can lead to higher drug levels and potential toxicity of relevant CYP3A4 substrates. Pharmacists should advise patients that these fruits should be avoided in any form (e.g. fruit or juice) with these medicines as there is no recommendation on the quantity that can be safely consumed. Beyond CYP3A4 substrates, it becomes more nuanced. For example, atenolol and fexofenadine aren’t metabolised by CYP3A4, yet both can have reduced bioavailability when taken with apple or orange juice – so patients taking these medicines should be advised to avoid these juices. When dispensing MAOIs, pharmacists should counsel patients to avoid tyramine-rich foods such as aged cheeses, cured meats, fermented products, yeast extract products and beer. Other certain foods and drinks must be consumed only in small amounts. MAOIs block the enzyme that normally breaks down tyramine, causing it to accumulate in the bloodstream, which can lead to a hypertensive crisis. Pharmacists should provide an MAOI card to patients, see APF Digital – Counselling advice for monoamine oxidase inhibitors.  It is important that pharmacists check a medicines’ approved PI to confirm the specific foods, fruits and juices that patients should avoid. Appropriate drug interaction resources (e.g. Stockley’s Drug Interactions) should also be used where needed when providing medicine-specific advice.

      When is the change happening?

      The CAL explanatory notes were updated in APF Digital today (7 May 2025). Pharmacists should familiarise themselves with the revised explanatory notes for CAL 18 in the digital Australian Pharmaceutical Formulary and Handbook.

      When will dispensing software be updated with the revised CALs?

      Pharmacists are advised to talk to their dispensing software provider, who can advise when these changes will be implemented.

      When will the new labels arrive?

      It is anticipated printers will commence printing of the new labels during their next print run. Until then, pharmacists should use the existing CAL 18 and CAL I – ensuring patients are equipped with the updated advice, available now in APF Digital which always contains the latest updates. [post_title] => Goodbye CAL I, hello expanded CAL 18 [post_excerpt] => Merging CAL 18 and CAL I removes duplication and confusion, helping patients receive clearer, more actionable dietary advice. [post_status] => publish [comment_status] => open [ping_status] => open [post_password] => [post_name] => goodbye-cal-i-hello-expanded-cal-18 [to_ping] => [pinged] => [post_modified] => 2025-05-07 17:21:44 [post_modified_gmt] => 2025-05-07 07:21:44 [post_content_filtered] => [post_parent] => 0 [guid] => https://www.australianpharmacist.com.au/?p=29310 [menu_order] => 0 [post_type] => post [post_mime_type] => [comment_count] => 0 [filter] => raw ) [title_attribute] => Goodbye CAL I, hello expanded CAL 18 [title] => Goodbye CAL I, hello expanded CAL 18 [href] => https://www.australianpharmacist.com.au/goodbye-cal-i-hello-expanded-cal-18/ [module_atts:td_module:private] => Array ( ) [td_review:protected] => Array ( ) [is_review:protected] => [post_thumb_id:protected] => 29315 [authorType] => )

      Goodbye CAL I, hello expanded CAL 18

      measles
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                  [post_date] => 2025-05-05 14:47:58
                  [post_date_gmt] => 2025-05-05 04:47:58
                  [post_content] => With measles cases climbing across Australia and pharmacies increasingly listed as exposure sites, community pharmacists must be prepared.
      
      
      Earlier this year, a patient who had just returned from Vietnam walked into Advantage Chesterville Pharmacy in Melbourne with a script for antibiotics.
      
      ‘She was wearing a face mask, and when I spoke to her she just said that she had a cough but she wasn't sure what the cough was from,’ said community pharmacist Minh Ngo MPS, who was on duty when the patient came through.
      
      Some time later, the pharmacy received word that the patient was infected with measles.
      
      ‘She either informed the hospital or the GP, but we just got a call from the [Victorian] Department of Health to notify us that we were an exposure case,’ she said.
      
      With measles spreading around Australia at an unprecedented rate, this is a position many pharmacists may soon find themselves in.
      
      Victoria is in the midst of its worst measles outbreak in a decade, with 25 cases recorded so far this year. New South Wales and Western Australia are not far behind, with 21 and 18 cases reported respectively.
      
      Healthcare settings such as pharmacies have been increasingly listed as exposure sites as people seek treatment for the highly infectious and virulent disease.
      
      Australian Pharmacist explores the steps pharmacists should take when confronted with this predicament.
      

      Patient contact tracing

      When a healthcare setting such as a pharmacy becomes a measles exposure site, it is responsible for contact tracing. ‘We had to inform every patient who was in the [pharmacy] at that time that we were informed that the exposure might have happened,’ Ms Ngo said.  This includes asking patients if they have any symptoms. Early symptoms of measles, before the rash appears, include:
      • fever 
      • tiredness 
      • cough 
      • runny nose
      • sore red eyes 
      • malaise.
      ‘We had to inform every patient who was in the [pharmacy] at that time that we were informed that the exposure might have happened.' MINH NGO MPS  

      Post-exposure testing and prophylaxis

      All symptomatic patients who were exposed to measles need to follow specific protocols.  ‘We told them that if they have any symptoms, if they develop any cough or if they have any concerns then go and get tested,’ Ms Ngo said.  Patients who have attended a known exposure site should be offered the Measles, Mumps, and Rubella vaccine within 72 hours of measles exposure to avert infection. In those who are unvaccinated or partially vaccinated, particularly young infants, pregnant people,, or immunocompromised patients – human immunoglobulin (NHIG) administered within six days of exposure may be appropriate. Pharmacists should advise patients with suspected measles to call ahead before visiting their healthcare provider for a PCR test and wear a mask upon leaving home. Suspected cases must remain isolated at home until laboratory testing confirms or excludes measles, avoiding work, school and any public venues. A notification must be made to the relevant department of health when symptoms are present via the patients' local public health unit.

      Important staff protocols

      Fortunately, there were only two members of staff on at the pharmacy including Ms Ngo at the time of the exposure, and neither was infected with measles.
      Local PHUs will identify any staff who may have been exposed to a measles case and assess their immunity status, said a spokesperson from the federal Department of Health and Aged Care. ‘Depending on their vaccination history, some staff members may need to be monitored or excluded from work during the infectious period to minimise the risk of further transmission – this could be for a period up to 18 days,’ the spokesperson said. ‘Post-exposure prophylaxis may be required and will be organised by the local PHU.’ With the number of cases currently floating around, pharmacists should ensure that staff are up to date with their vaccinations in advance All adults born between 1966 and 1992 and who do not have documented evidence of vaccination are eligible for a catch-up vaccine to ensure maximum protection against measles, with the two-dose schedule of the MMR vaccine only being introduced in Australia in 1992. https://twitter.com/VicGovDH/status/1916756251293409486 Should a patient present with a fever and rash, they should be moved out of communal waiting areas and into a dedicated space. If measles is suspected, the patient should be given a disposable, well-sealed mask. [post_title] => Responding to a measles exposure in your pharmacy [post_excerpt] => With measles cases climbing across Australia and pharmacies increasingly listed as exposure sites, community pharmacists must be prepared. [post_status] => publish [comment_status] => open [ping_status] => open [post_password] => [post_name] => responding-to-a-measles-exposure-in-your-pharmacy [to_ping] => [pinged] => [post_modified] => 2025-05-06 10:32:42 [post_modified_gmt] => 2025-05-06 00:32:42 [post_content_filtered] => [post_parent] => 0 [guid] => https://www.australianpharmacist.com.au/?p=29295 [menu_order] => 0 [post_type] => post [post_mime_type] => [comment_count] => 0 [filter] => raw ) [title_attribute] => Responding to a measles exposure in your pharmacy [title] => Responding to a measles exposure in your pharmacy [href] => https://www.australianpharmacist.com.au/responding-to-a-measles-exposure-in-your-pharmacy/ [module_atts:td_module:private] => Array ( ) [td_review:protected] => Array ( ) [is_review:protected] => [post_thumb_id:protected] => 29305 [authorType] => )

      Responding to a measles exposure in your pharmacy

      esketamine
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                  [post_date] => 2025-04-30 11:57:51
                  [post_date_gmt] => 2025-04-30 01:57:51
                  [post_content] => From 1 May, Spravato (esketamine) will be subsidised under the Pharmaceutical Benefits Scheme (PBS) for adults with treatment-resistant depression, intended for use alongside a newly initiated oral antidepressant.
      
      Up to 30,000 Australians are anticipated to access esketamine via the PBS, paying only $7.70 per dose with a pensioner or concession card, or $31.60 per dose for general patients.
      
      [caption id="attachment_29259" align="alignright" width="233"] Professor Malcolm Hopwood[/caption]
      
      Australian Pharmacist spoke with Professor Malcolm Hopwood, Ramsay Health Care Professor of Psychiatry at the University of Melbourne, about the treatment process and how pharmacists will be involved.
      

      How effective is esketamine in managing treatment resistant depression?

      The largest clinical trials on esketamine efficacy found that about 50% of patients who had not responded to two or three antidepressants did respond to esketamine, Prof Hopwood said. ‘If you compare that to trialing one of the usual medicines, the response rate for the third or fourth [medicine] is probably only about 15%,’ he said. ‘So it’s quite a jump up in terms of response rate.’

      Who is eligible to be prescribed esketamine nasal spray?

      Those diagnosed with treatment-resistant depression, defined as major depressive disorder that has not responded sufficiently to at least two different antidepressants, each administered at an adequate dose and duration, for the treatment of the current moderate to severe depressive episode.

      Who is not a good candidate for this treatment?

      Esketamine is currently not indicated for bipolar depression. And caution should be taken for patients with psychotic depression, Prof Hopwood said.  ‘[This is] because ketamine, when used in much higher doses, has psychogenic potential,’ Prof Hopwood said. There is also a precautionary note in the product information around patients with marked hepatic or renal impairment. ‘In terms of drug-drug interactions, it should not be used together with an irreversible monoamine oxidase inhibitor, which these days is only Parnate,’ he said. ‘While not widely used now, it's an important interaction to be aware of.’

      What’s the duration of therapy?

      Esketamine is initially administered twice weekly for the first 4 weeks, Prof Hopwood said. ‘By the end of that 4-week period, we've usually got a sense whether you're a responder or not.’ Treatment usually stops in non-responders, with responders moving to a once-weekly treatment regimen. ‘Eventually, fortnightly treatment for a 6-month maintenance period is what we recommend,’ Prof Hopwood said.

      Is re-treatment recommended?

      Given that depression is a highly recurrent condition, it is likely some patients will relapse post treatment. And re-treatment with esketamine could prove beneficial, Prof Hopwood said. ‘There is some data about re-treatment …  [with] evidence showing that responders do seem to have a good response rate the second time around,’ he said. ‘That will be permitted under this funding scheme.’

      How is esketamine supplied?

      Patients cannot be in possession of the spray until they are in the clinic for administration under supervision, Prof Hopwood said.  ‘Esketamine needs to be administered in an approved treatment center that involves close supervision for side effects such as dissociation and hypertension,’ he said.  Appropriate pharmacist handling of a Schedule 8 medicine is also required. ‘In our facility, we are fortunate to have an on-site pharmacist who dispenses [the medicine] to a nurse, and then the patient self-administers,’ Prof Hopwood said.  ‘But the patient neither brings the medicine to the clinic or takes it away. The intent … is to reduce the risk of diversion.’ Facilities that do not have an on-site pharmacist must establish and demonstrate a connection with a local community pharmacy to qualify as an approved treatment centre.

      Is talk therapy involved in the session?

      Treatment with esketamine does not involve psychotherapy. However, there is a small body of research currently looking at ketamine-facilitated psychotherapy, Prof Hopwood said. ‘We still don't know whether that offers additional benefit for many patients, [but] if esketamine proves an effective treatment for their depression, they may be able to utilise psychotherapy much more effectively – which they might not be able to do when severely depressed.’

      What are the estimated costs of esketamine sessions?

      The estimated cost is $300–$350 per treatment session, Prof Hopwood said. In most clinics, the doctor will see the patient on treatment occasions, but less so as treatment becomes established. ‘If the doctor does visit before the treatment is administered, then they can claim through Medicare as per usual,’ he said. ‘But the nursing and pharmacy [costs] will not be covered.’

      Are patients supposed to disassociate when they take esketamine?

      Dissociation with treatment is frequent, albeit mild and transient for most patients, Prof Hopwood said. ‘For up to half an hour they [may] feel a little dreamy and not unpleasant,’ he said.  Some evidence suggests that mild dissociative effects may be required for the drug to be effective in the treatment of depression, although this is not definitive, Prof Hopwood said. ‘We monitor patients during that time and keep them safe,’ he said. ‘Most of them simply want to lie there and listen to music or just bliss out for a short period of time.’  While there is no reversal agent for esketamine, any periods of distress are typically short lived. ‘We've had a very small number of patients distressed, consistent with the trials,’ Prof Hopwood said. ‘And they've generally responded to quite simple reassurance.’ Patients’ blood pressure is also monitored ‘It's rarely severe enough that intervention is required, but there can be a transient increase, as we've known from the use of ketamine as an anaesthetic,’ he said.

      Where should pharmacists refer interested patients?

      GPs are an important resource for knowing where the available treatment centers are, Prof Hopwood said.  ‘There is a list of those available, and I predict that number may increase over time now that esketamine is funded.’ There are high levels of patient interest in esketamine and psychedelics, Prof Hopwood said. ‘So it's important they receive accurate, quality information that includes realistic expectations about the likelihood of treatment response and what's involved,’ he said. ‘And pharmacists are very well placed to provide that kind of information.’

      What is preferable: esketamine or psychedelics?

      Since 1 July 2023, patients with treatment-resistant depression have legally been allowed to receive treatment with psilocybin and MDMA, under specific conditions.   There is a degree of overlap between the patient populations considered suitable for ketamine and psychedelic therapy, Prof Hopwood said. ‘Most of the current guidance, including from The Royal Australian and New Zealand College of Psychiatrists, would say that psychedelic therapy is still more at a research level,’ he said.  ‘Whereas, esketamine, reflected in the funding, has reached a higher level of evidence at this point.  ‘So I would certainly see it as coming before psychedelic therapy in any hierarchy.’ To find out more about the use of psilocybin for treatment-resistant depression, read Australian Pharmacist's CPD article on the therapeutic potential of psychedelics. [post_title] => PBS-backed esketamine rolls out for depression with S8 controls [post_excerpt] => Esketamine will soon be funded for treatment-resistant depression, requiring pharmacists to adhere to strict supply and handling conditions. [post_status] => publish [comment_status] => open [ping_status] => open [post_password] => [post_name] => pbs-backed-esketamine-rolls-out-for-depression-with-s8-controls [to_ping] => [pinged] => [post_modified] => 2025-04-30 15:17:32 [post_modified_gmt] => 2025-04-30 05:17:32 [post_content_filtered] => [post_parent] => 0 [guid] => https://www.australianpharmacist.com.au/?p=29255 [menu_order] => 0 [post_type] => post [post_mime_type] => [comment_count] => 0 [filter] => raw ) [title_attribute] => PBS-backed esketamine rolls out for depression with S8 controls [title] => PBS-backed esketamine rolls out for depression with S8 controls [href] => https://www.australianpharmacist.com.au/pbs-backed-esketamine-rolls-out-for-depression-with-s8-controls/ [module_atts:td_module:private] => Array ( ) [td_review:protected] => Array ( ) [is_review:protected] => [post_thumb_id:protected] => 29258 [authorType] => )

      PBS-backed esketamine rolls out for depression with S8 controls

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                  [post_date] => 2025-04-30 11:38:14
                  [post_date_gmt] => 2025-04-30 01:38:14
                  [post_content] => 

      Rosa is a 35-year-old professional struggling with persistent sleep disturbances. Despite maintaining a consistent sleep routine, exercising regularly, and avoiding heavy meals before bedtime, she found herself regularly waking during the night.

      The consultation

      [caption id="attachment_27686" align="alignright" width="300"]allergic rhinitis This article is sponsored by Kenvue.[/caption]

      Before providing Rosa a sleep aid such as melatonin supplements, you ask a series of questions to identify potential contributing factors for her condition and to determine if a sleep aid is the best treatment option.

      Key questions to ask

      Medical history:

      • Do you have a history of allergies or asthma?
      • Does anyone in your family have allergies or asthma?

      Duration of symptoms:

      • How long have you noticed symptoms?

      Symptom pattern:

      • Are the sleep disturbances worse at specific times of the year?

      Nasal symptoms:

      • Do you experience nasal congestion or breathing difficulties at night?
      • Have you noticed an increase in sneezing or runny nose lately?
      • Have you noticed any postnasal drip or coughing during the night?

      Sensory Irritation:

      • Do you experience any itching in your nose, eyes or throat?
      • Do your sleep problems coincide with other symptoms such as headaches or sinus pressure?

      Environmental factors:

      • Have there been any recent changes in your living environment that could be contributing to your symptoms?
      • Have you recently introduced new furniture, carpets or other items into your home that might be contributing to your symptoms?
      • Do you have pets in your home? If so, do you notice any worsening of symptoms when they are nearby?
      • Have you noticed any improvement in your sleep when you’re away from your usual environment?

      Timing of symptoms:

      • Are your symptoms worse in the morning or at night?

      Current approaches:

      • How have you been trying to improve your sleep?
      • Have you tried any allergy avoidance strategies such as using air purifiers or keeping pets out of the bedroom?
      • Do you use nasal sprays or other medications for congestion? If so, how often?

      Current medical status and medications:

      • Do you have any other health conditions?
      • Do you currently take any medication?

      The diagnosis

      Rosa reveals that when she wakes, she frequently has a blocked nose and itchy eyes, and she sneezes a lot in the evening before bed. She has suffered from very mild hayfever before but never at this time of year.

      You suspect allergic rhinitis as the root cause. Rosa was surprised. Like many, she had dismissed her nasal congestion as a minor annoyance rather than a significant factor affecting her rest. She didn’t even think one could get hayfever in winter.

      The treatment plan

      You recommend a treatment plan to tackle the root cause of Rosa’s sleep disturbances. With proper treatment, she can manage her symptoms and improve sleep quality. Alongside managing environmental exposure you can recommend an antihistamine like:

      Zyrtec Rapid Acting Allergy Antihistamine and Hayfever Tablets

      Dosage: One tablet daily offers 24-hour protection.

      You can also recommend Rhinocort nasal spray to be used when symptoms become acute.1

      The outcome: restful nights and restored energy

      Within days of following the treatment plan, Rosa noticed a remarkable improvement. Her congestion eased, she wasn’t waking up anymore, and she finally felt refreshed and energised throughout the day.

      By looking beyond the immediate request for sleep aids, the pharmacist was able to identify the true cause of Rosa’s problem and offer a more effective, long-term solution.

      Allergic rhinitis (AR) and sleep disruptions

      Allergic rhinitis (AR), commonly known as hayfever, affects around 19% of Australians.2 Chronic nasalcongestion and other symptoms of allergic rhinitis can significantly impact sleep quality.3 This often results in daytime fatigue, decreased productivity, and impaired cognitive function. Patients may not realise that their persistent tiredness or difficulty concentrating stems from untreated allergies. Zyrtec works fast for hayfever relief and stays strong, day after day offering 24-hour relief from multiple symptoms.

      Zyrtec works fast for hay fever relief and stays strong, day after day.4

      If your patient is struggling with unexplained sleep disturbances, allergies could be the hidden cause.

      With the right management you can help them to reclaim restful sleep and feel their best every day.

      References

      1. Approach to management of allergic rhinitis, [2020; amended July 2024]. In: Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited.
      2. Definition and causes of allergic rhinitis, [2020; amended July 2024]. In: Therapeutic Guidelines.Melbourne: Therapeutic Guidelines Limited.
      3. Wise SK, Damask C, Roland LT, et al. International consensus statement on allergy and rhinology: Allergic rhinitis.
      4. Urdaneta E, et al. Ann Allergy Asthma Immunol 2010;105(5):A121. (Sponsored by Zyrtec.)

      [post_title] => Allergic rhinitis and sleep deprivation: What’s going undetected? [post_excerpt] => Allergic rhinitis (AR), commonly known as hayfever, affects around 19% of Australians. This case study explores how it impacts sleep quality. [post_status] => publish [comment_status] => open [ping_status] => open [post_password] => [post_name] => allergic-rhinitis-and-sleep-deprivation [to_ping] => [pinged] => [post_modified] => 2025-05-05 12:50:52 [post_modified_gmt] => 2025-05-05 02:50:52 [post_content_filtered] => [post_parent] => 0 [guid] => https://www.australianpharmacist.com.au/?p=29210 [menu_order] => 0 [post_type] => post [post_mime_type] => [comment_count] => 0 [filter] => raw ) [title_attribute] => Allergic rhinitis and sleep deprivation: What’s going undetected? [title] => Allergic rhinitis and sleep deprivation: What’s going undetected? [href] => https://www.australianpharmacist.com.au/allergic-rhinitis-and-sleep-deprivation/ [module_atts:td_module:private] => Array ( ) [td_review:protected] => Array ( ) [is_review:protected] => [post_thumb_id:protected] => 29273 [authorType] => )

      Allergic rhinitis and sleep deprivation: What’s going undetected?

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                  [post_date] => 2025-04-22 11:19:25
                  [post_date_gmt] => 2025-04-22 01:19:25
                  [post_content] => 

      Aside from administering medicines by injection, Queensland-based community pharmacist Fiona Watson MPS loves tearing up a Latin dance floor.

      Tell us about your pharmacy career.

      I had a varied early career, moving to North Queensland for a year shortly after I graduated as well as locuming around Australia for a while.

      This gave me a great introduction to community pharmacy and a lot of different experiences – both good and bad. When locuming, you develop a clear idea of the factors that contribute to a well-run pharmacy.

      I then moved to the United Kingdom where I completed a Certificate in Clinical Pharmacy. You can tell how old I am because I was one of the last pharmacists able to register in the UK with only a month under supervision.

      I was a ‘rotational resident pharmacist’, living on-site at the hospital. I covered renal, gastro, cardiology, oncology, aged care, palliative care and surgery wards.

      We worked on call overnight, and could get called upon to help with all sorts of different situations – one of the most interesting being calculating the correct dose for the antidote to antifreeze.

      More recently, I was very fortunate to be given the opportunity to go into partnership with my mum and sister, both pharmacists, as the managing partner at Redland Bay Wholelife Pharmacy and Healthfoods.

      What medicines do you administer by injection?

      About 10 years ago, I became a trained vaccinator administering thousands of vaccines during the COVID-19 pandemic.

      When Queensland allowed pharmacists to expand the range of medicines they could administer, I completed the Medication Administration course, as I believe this is an essential skill for pharmacists to have.

      So many new medications are injectable, and for some patients self-administration just isn’t an option. We were one of the first pharmacies in our area to offer long-acting injectable buprenorphine services, which can be a life-changing option for patients.

      Tell us about your administering injections beyond vaccines.

      The majority of pharmacists I work with at Redland Bay are trained vaccinators and have completed medicines administration courses. When we come across a new medication that requires administration by injection we collate the available information from the manufacturer and ensure everyone has read it. Many companies, such as Novartis with inclisiran (Leqvio), have reps who are happy to provide additional training.

      Once you are comfortable with subcutaneous injections, it’s a matter of familiarising yourself with the different types of devices available. It seemed a logical step for us to provide this service. We have great consult room facilities and it brings variety to our role.

      What role do you see pharmacists playing in cardiovascular care in future?

      The sky is the limit. We’re on the cusp of a fundamental change in the way Australians receive health care and I hope to see pharmacists embrace the opportunities this will bring.

      There’s a workforce crisis and an ageing population, so we need to become more efficient and accessible. If you think about how much the role of a nurse practitioner has changed in the last 10–15 years, you can see where pharmacists have even greater potential. A patient with a diagnosis of heart failure should be able to be titrated to optimum therapy by a pharmacist in a community pharmacy. A patient should have their HbA1c or lipids checked in the pharmacy, with appropriate therapy initiated or adjusted. We should also be actively involved in screening and chronic disease management.

      Pharmacy is an incredibly rewarding and enjoyable career, and now is an especially exciting time to be a pharmacist. There is just so much opportunity. 

      Day in the life of Fiona Watson MPS, Community pharmacist at Redland Bay Wholelife Pharmacy, QLD.

      5.00am

      Hit the gym

      I get up and do a HIIT or Muay Thai class most mornings for positive effects on my mental health. Passionate about preventative health care, I see the long-term effects of patients’ lifestyle choices every day.

      8.00am

      Open the pharmacy Every day is different. At least two pharmacists are rostered on, ensuring we give each patient the time they need while providing a wide range of different services.

      9.00am

      Vaccination service

      Embarking on a cruise in 2 months, a couple in their 60s asks about  COVID-19 vaccines. More than 12 months since their last vaccine they are  happy to be vaccinated on the spot. Not wanting more than one vaccine at a time, we book them in for a follow-up appointment in a month for the shingles vaccination.

      10.00am

      Collaborative care

      A local GP phones about a recently discharged mutual patient who’s not coping well on his new medicines. We spend some time with the patient doing a medicine review and setting up his profile for a dose administration aid.

      1.00pm

      Lunchtime

      It’s important that all staff, especially pharmacists, prioritise their breaks. We all need a little downtime to reset and refresh.

      1.30pm

      Medicines injection

      A regular patient comes in for her second dose of inclisiran (Leqvio) after I administered her first 3 months ago. She is happy with the more convenient option than visiting her GP.

      3.00pm

      Infection control

      In a call from our pharmacy car park, we learn a patient has tested positive for COVID-19 and has an e-script. We dispense and counsel over the phone and then deliver out to their car (with appropriate precautions).

      6.30pm

      OCP continuance

      A stressed young woman, with a 2-week wait for a GP appointment, has run out of her pill. She is relieved when seen by a colleague who prescribes Estelle under the Queensland Hormonal Contraceptive Pilot. I dispense it.

      [post_title] => Injectable medication administration an essential skill [post_excerpt] => Aside from administering medicines by injection, Queensland-based community pharmacist Fiona Watson MPS loves tearing up a Latin dance floor. [post_status] => publish [comment_status] => open [ping_status] => open [post_password] => [post_name] => injectable-medication-administration-an-essential-skill [to_ping] => [pinged] => [post_modified] => 2025-04-30 11:28:21 [post_modified_gmt] => 2025-04-30 01:28:21 [post_content_filtered] => [post_parent] => 0 [guid] => https://www.australianpharmacist.com.au/?p=29196 [menu_order] => 0 [post_type] => post [post_mime_type] => [comment_count] => 0 [filter] => raw ) [title_attribute] => Injectable medication administration an essential skill [title] => Injectable medication administration an essential skill [href] => https://www.australianpharmacist.com.au/injectable-medication-administration-an-essential-skill/ [module_atts:td_module:private] => Array ( ) [td_review:protected] => Array ( ) [is_review:protected] => [post_thumb_id:protected] => 29197 [authorType] => )

      Injectable medication administration an essential skill

  • CPD
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                  [post_date] => 2025-05-07 14:26:37
                  [post_date_gmt] => 2025-05-07 04:26:37
                  [post_content] => Merging CAL 18 and CAL I removes duplication and confusion, helping patients receive clearer, more actionable dietary advice.
      
      Australian Pharmacist explores what pharmacists and patients need to know.
      
      What’s changing?
      
      Cautionary advisory label (CAL) 18 and CAL I currently provide dietary advice for specific medicines:
      
      [caption id="attachment_29312" align="aligncenter" width="151"] CAL 18[/caption]
      
      [caption id="attachment_29311" align="aligncenter" width="152"] CAL I[/caption]
      

      Instead of having two labels that relate to avoiding certain foods and juices (CAL 18 and CAL I), there will now be one – an updated CAL 18.

      [caption id="attachment_29313" align="aligncenter" width="189"] Revised CAL 18[/caption]

      What’s the rationale?

      Currently, CAL 18 only warns about grapefruit due to its effect on the bioavailability of certain medicines through the selective inhibition of cytochrome P450 3A4 isoenzymes. But the product information (PI) for new medicines that are substrates for CYP3A4 increasingly mention other fruits (beyond just grapefruit) as interacting with medicines via inhibition of CYP3A4. This includes seville oranges, pomelo, star fruit, bitter melon and pomegranate.  As it stands, the wording of CAL 18 is not broad enough to cover these scenarios. CAL I is currently used to advise patients about fruits and juices that interact with medicines through mechanisms other than inhibition of CYP3A4.  For example, food and drink interactions with non-selective monoamine oxidase inhibitors (MAOIs) and interactions between medicines and fruit juices through mechanisms other than CYP3A4 inhibition (e.g. fexofenadine, which has been found to interact with orange and apple juice).  However, there have been reports of confusion associated with ‘I’ appearing very similar to ‘1’ in the CAL recommendation table. There are also not many medicines CAL I is relevant to at present, so it therefore has limited applicability.  The revised CAL 18, now reading ‘Certain foods and fruit juices should be avoided while being treated with this medicine’, will now cover:
      • interactions with all CYP3A4-inhibiting fruits (for example, grapefruit, Seville orange, pomelo, pomegranate, star fruit) 
      • any newly identified food and juice interactions with medicines – even those that don’t occur by CYP3A4 (e.g. apple and orange juice); and
      • other food and drink interactions with medicines (e.g. foods and drinks rich in tyramine with MAOIs).

      How should pharmacists respond when patients ask which foods and fruit juices should be avoided?

      For those fruits that can inhibit CYP3A4 (e.g. grapefruit, Seville orange, pomelo, star fruit, bitter melon and pomegranate), this can lead to higher drug levels and potential toxicity of relevant CYP3A4 substrates. Pharmacists should advise patients that these fruits should be avoided in any form (e.g. fruit or juice) with these medicines as there is no recommendation on the quantity that can be safely consumed. Beyond CYP3A4 substrates, it becomes more nuanced. For example, atenolol and fexofenadine aren’t metabolised by CYP3A4, yet both can have reduced bioavailability when taken with apple or orange juice – so patients taking these medicines should be advised to avoid these juices. When dispensing MAOIs, pharmacists should counsel patients to avoid tyramine-rich foods such as aged cheeses, cured meats, fermented products, yeast extract products and beer. Other certain foods and drinks must be consumed only in small amounts. MAOIs block the enzyme that normally breaks down tyramine, causing it to accumulate in the bloodstream, which can lead to a hypertensive crisis. Pharmacists should provide an MAOI card to patients, see APF Digital – Counselling advice for monoamine oxidase inhibitors.  It is important that pharmacists check a medicines’ approved PI to confirm the specific foods, fruits and juices that patients should avoid. Appropriate drug interaction resources (e.g. Stockley’s Drug Interactions) should also be used where needed when providing medicine-specific advice.

      When is the change happening?

      The CAL explanatory notes were updated in APF Digital today (7 May 2025). Pharmacists should familiarise themselves with the revised explanatory notes for CAL 18 in the digital Australian Pharmaceutical Formulary and Handbook.

      When will dispensing software be updated with the revised CALs?

      Pharmacists are advised to talk to their dispensing software provider, who can advise when these changes will be implemented.

      When will the new labels arrive?

      It is anticipated printers will commence printing of the new labels during their next print run. Until then, pharmacists should use the existing CAL 18 and CAL I – ensuring patients are equipped with the updated advice, available now in APF Digital which always contains the latest updates. [post_title] => Goodbye CAL I, hello expanded CAL 18 [post_excerpt] => Merging CAL 18 and CAL I removes duplication and confusion, helping patients receive clearer, more actionable dietary advice. [post_status] => publish [comment_status] => open [ping_status] => open [post_password] => [post_name] => goodbye-cal-i-hello-expanded-cal-18 [to_ping] => [pinged] => [post_modified] => 2025-05-07 17:21:44 [post_modified_gmt] => 2025-05-07 07:21:44 [post_content_filtered] => [post_parent] => 0 [guid] => https://www.australianpharmacist.com.au/?p=29310 [menu_order] => 0 [post_type] => post [post_mime_type] => [comment_count] => 0 [filter] => raw ) [title_attribute] => Goodbye CAL I, hello expanded CAL 18 [title] => Goodbye CAL I, hello expanded CAL 18 [href] => https://www.australianpharmacist.com.au/goodbye-cal-i-hello-expanded-cal-18/ [module_atts:td_module:private] => Array ( ) [td_review:protected] => Array ( ) [is_review:protected] => [post_thumb_id:protected] => 29315 [authorType] => )

      Goodbye CAL I, hello expanded CAL 18

      measles
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                  [post_date] => 2025-05-05 14:47:58
                  [post_date_gmt] => 2025-05-05 04:47:58
                  [post_content] => With measles cases climbing across Australia and pharmacies increasingly listed as exposure sites, community pharmacists must be prepared.
      
      
      Earlier this year, a patient who had just returned from Vietnam walked into Advantage Chesterville Pharmacy in Melbourne with a script for antibiotics.
      
      ‘She was wearing a face mask, and when I spoke to her she just said that she had a cough but she wasn't sure what the cough was from,’ said community pharmacist Minh Ngo MPS, who was on duty when the patient came through.
      
      Some time later, the pharmacy received word that the patient was infected with measles.
      
      ‘She either informed the hospital or the GP, but we just got a call from the [Victorian] Department of Health to notify us that we were an exposure case,’ she said.
      
      With measles spreading around Australia at an unprecedented rate, this is a position many pharmacists may soon find themselves in.
      
      Victoria is in the midst of its worst measles outbreak in a decade, with 25 cases recorded so far this year. New South Wales and Western Australia are not far behind, with 21 and 18 cases reported respectively.
      
      Healthcare settings such as pharmacies have been increasingly listed as exposure sites as people seek treatment for the highly infectious and virulent disease.
      
      Australian Pharmacist explores the steps pharmacists should take when confronted with this predicament.
      

      Patient contact tracing

      When a healthcare setting such as a pharmacy becomes a measles exposure site, it is responsible for contact tracing. ‘We had to inform every patient who was in the [pharmacy] at that time that we were informed that the exposure might have happened,’ Ms Ngo said.  This includes asking patients if they have any symptoms. Early symptoms of measles, before the rash appears, include:
      • fever 
      • tiredness 
      • cough 
      • runny nose
      • sore red eyes 
      • malaise.
      ‘We had to inform every patient who was in the [pharmacy] at that time that we were informed that the exposure might have happened.' MINH NGO MPS  

      Post-exposure testing and prophylaxis

      All symptomatic patients who were exposed to measles need to follow specific protocols.  ‘We told them that if they have any symptoms, if they develop any cough or if they have any concerns then go and get tested,’ Ms Ngo said.  Patients who have attended a known exposure site should be offered the Measles, Mumps, and Rubella vaccine within 72 hours of measles exposure to avert infection. In those who are unvaccinated or partially vaccinated, particularly young infants, pregnant people,, or immunocompromised patients – human immunoglobulin (NHIG) administered within six days of exposure may be appropriate. Pharmacists should advise patients with suspected measles to call ahead before visiting their healthcare provider for a PCR test and wear a mask upon leaving home. Suspected cases must remain isolated at home until laboratory testing confirms or excludes measles, avoiding work, school and any public venues. A notification must be made to the relevant department of health when symptoms are present via the patients' local public health unit.

      Important staff protocols

      Fortunately, there were only two members of staff on at the pharmacy including Ms Ngo at the time of the exposure, and neither was infected with measles.
      Local PHUs will identify any staff who may have been exposed to a measles case and assess their immunity status, said a spokesperson from the federal Department of Health and Aged Care. ‘Depending on their vaccination history, some staff members may need to be monitored or excluded from work during the infectious period to minimise the risk of further transmission – this could be for a period up to 18 days,’ the spokesperson said. ‘Post-exposure prophylaxis may be required and will be organised by the local PHU.’ With the number of cases currently floating around, pharmacists should ensure that staff are up to date with their vaccinations in advance All adults born between 1966 and 1992 and who do not have documented evidence of vaccination are eligible for a catch-up vaccine to ensure maximum protection against measles, with the two-dose schedule of the MMR vaccine only being introduced in Australia in 1992. https://twitter.com/VicGovDH/status/1916756251293409486 Should a patient present with a fever and rash, they should be moved out of communal waiting areas and into a dedicated space. If measles is suspected, the patient should be given a disposable, well-sealed mask. [post_title] => Responding to a measles exposure in your pharmacy [post_excerpt] => With measles cases climbing across Australia and pharmacies increasingly listed as exposure sites, community pharmacists must be prepared. [post_status] => publish [comment_status] => open [ping_status] => open [post_password] => [post_name] => responding-to-a-measles-exposure-in-your-pharmacy [to_ping] => [pinged] => [post_modified] => 2025-05-06 10:32:42 [post_modified_gmt] => 2025-05-06 00:32:42 [post_content_filtered] => [post_parent] => 0 [guid] => https://www.australianpharmacist.com.au/?p=29295 [menu_order] => 0 [post_type] => post [post_mime_type] => [comment_count] => 0 [filter] => raw ) [title_attribute] => Responding to a measles exposure in your pharmacy [title] => Responding to a measles exposure in your pharmacy [href] => https://www.australianpharmacist.com.au/responding-to-a-measles-exposure-in-your-pharmacy/ [module_atts:td_module:private] => Array ( ) [td_review:protected] => Array ( ) [is_review:protected] => [post_thumb_id:protected] => 29305 [authorType] => )

      Responding to a measles exposure in your pharmacy

      esketamine
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                  [post_content] => From 1 May, Spravato (esketamine) will be subsidised under the Pharmaceutical Benefits Scheme (PBS) for adults with treatment-resistant depression, intended for use alongside a newly initiated oral antidepressant.
      
      Up to 30,000 Australians are anticipated to access esketamine via the PBS, paying only $7.70 per dose with a pensioner or concession card, or $31.60 per dose for general patients.
      
      [caption id="attachment_29259" align="alignright" width="233"] Professor Malcolm Hopwood[/caption]
      
      Australian Pharmacist spoke with Professor Malcolm Hopwood, Ramsay Health Care Professor of Psychiatry at the University of Melbourne, about the treatment process and how pharmacists will be involved.
      

      How effective is esketamine in managing treatment resistant depression?

      The largest clinical trials on esketamine efficacy found that about 50% of patients who had not responded to two or three antidepressants did respond to esketamine, Prof Hopwood said. ‘If you compare that to trialing one of the usual medicines, the response rate for the third or fourth [medicine] is probably only about 15%,’ he said. ‘So it’s quite a jump up in terms of response rate.’

      Who is eligible to be prescribed esketamine nasal spray?

      Those diagnosed with treatment-resistant depression, defined as major depressive disorder that has not responded sufficiently to at least two different antidepressants, each administered at an adequate dose and duration, for the treatment of the current moderate to severe depressive episode.

      Who is not a good candidate for this treatment?

      Esketamine is currently not indicated for bipolar depression. And caution should be taken for patients with psychotic depression, Prof Hopwood said.  ‘[This is] because ketamine, when used in much higher doses, has psychogenic potential,’ Prof Hopwood said. There is also a precautionary note in the product information around patients with marked hepatic or renal impairment. ‘In terms of drug-drug interactions, it should not be used together with an irreversible monoamine oxidase inhibitor, which these days is only Parnate,’ he said. ‘While not widely used now, it's an important interaction to be aware of.’

      What’s the duration of therapy?

      Esketamine is initially administered twice weekly for the first 4 weeks, Prof Hopwood said. ‘By the end of that 4-week period, we've usually got a sense whether you're a responder or not.’ Treatment usually stops in non-responders, with responders moving to a once-weekly treatment regimen. ‘Eventually, fortnightly treatment for a 6-month maintenance period is what we recommend,’ Prof Hopwood said.

      Is re-treatment recommended?

      Given that depression is a highly recurrent condition, it is likely some patients will relapse post treatment. And re-treatment with esketamine could prove beneficial, Prof Hopwood said. ‘There is some data about re-treatment …  [with] evidence showing that responders do seem to have a good response rate the second time around,’ he said. ‘That will be permitted under this funding scheme.’

      How is esketamine supplied?

      Patients cannot be in possession of the spray until they are in the clinic for administration under supervision, Prof Hopwood said.  ‘Esketamine needs to be administered in an approved treatment center that involves close supervision for side effects such as dissociation and hypertension,’ he said.  Appropriate pharmacist handling of a Schedule 8 medicine is also required. ‘In our facility, we are fortunate to have an on-site pharmacist who dispenses [the medicine] to a nurse, and then the patient self-administers,’ Prof Hopwood said.  ‘But the patient neither brings the medicine to the clinic or takes it away. The intent … is to reduce the risk of diversion.’ Facilities that do not have an on-site pharmacist must establish and demonstrate a connection with a local community pharmacy to qualify as an approved treatment centre.

      Is talk therapy involved in the session?

      Treatment with esketamine does not involve psychotherapy. However, there is a small body of research currently looking at ketamine-facilitated psychotherapy, Prof Hopwood said. ‘We still don't know whether that offers additional benefit for many patients, [but] if esketamine proves an effective treatment for their depression, they may be able to utilise psychotherapy much more effectively – which they might not be able to do when severely depressed.’

      What are the estimated costs of esketamine sessions?

      The estimated cost is $300–$350 per treatment session, Prof Hopwood said. In most clinics, the doctor will see the patient on treatment occasions, but less so as treatment becomes established. ‘If the doctor does visit before the treatment is administered, then they can claim through Medicare as per usual,’ he said. ‘But the nursing and pharmacy [costs] will not be covered.’

      Are patients supposed to disassociate when they take esketamine?

      Dissociation with treatment is frequent, albeit mild and transient for most patients, Prof Hopwood said. ‘For up to half an hour they [may] feel a little dreamy and not unpleasant,’ he said.  Some evidence suggests that mild dissociative effects may be required for the drug to be effective in the treatment of depression, although this is not definitive, Prof Hopwood said. ‘We monitor patients during that time and keep them safe,’ he said. ‘Most of them simply want to lie there and listen to music or just bliss out for a short period of time.’  While there is no reversal agent for esketamine, any periods of distress are typically short lived. ‘We've had a very small number of patients distressed, consistent with the trials,’ Prof Hopwood said. ‘And they've generally responded to quite simple reassurance.’ Patients’ blood pressure is also monitored ‘It's rarely severe enough that intervention is required, but there can be a transient increase, as we've known from the use of ketamine as an anaesthetic,’ he said.

      Where should pharmacists refer interested patients?

      GPs are an important resource for knowing where the available treatment centers are, Prof Hopwood said.  ‘There is a list of those available, and I predict that number may increase over time now that esketamine is funded.’ There are high levels of patient interest in esketamine and psychedelics, Prof Hopwood said. ‘So it's important they receive accurate, quality information that includes realistic expectations about the likelihood of treatment response and what's involved,’ he said. ‘And pharmacists are very well placed to provide that kind of information.’

      What is preferable: esketamine or psychedelics?

      Since 1 July 2023, patients with treatment-resistant depression have legally been allowed to receive treatment with psilocybin and MDMA, under specific conditions.   There is a degree of overlap between the patient populations considered suitable for ketamine and psychedelic therapy, Prof Hopwood said. ‘Most of the current guidance, including from The Royal Australian and New Zealand College of Psychiatrists, would say that psychedelic therapy is still more at a research level,’ he said.  ‘Whereas, esketamine, reflected in the funding, has reached a higher level of evidence at this point.  ‘So I would certainly see it as coming before psychedelic therapy in any hierarchy.’ To find out more about the use of psilocybin for treatment-resistant depression, read Australian Pharmacist's CPD article on the therapeutic potential of psychedelics. [post_title] => PBS-backed esketamine rolls out for depression with S8 controls [post_excerpt] => Esketamine will soon be funded for treatment-resistant depression, requiring pharmacists to adhere to strict supply and handling conditions. [post_status] => publish [comment_status] => open [ping_status] => open [post_password] => [post_name] => pbs-backed-esketamine-rolls-out-for-depression-with-s8-controls [to_ping] => [pinged] => [post_modified] => 2025-04-30 15:17:32 [post_modified_gmt] => 2025-04-30 05:17:32 [post_content_filtered] => [post_parent] => 0 [guid] => https://www.australianpharmacist.com.au/?p=29255 [menu_order] => 0 [post_type] => post [post_mime_type] => [comment_count] => 0 [filter] => raw ) [title_attribute] => PBS-backed esketamine rolls out for depression with S8 controls [title] => PBS-backed esketamine rolls out for depression with S8 controls [href] => https://www.australianpharmacist.com.au/pbs-backed-esketamine-rolls-out-for-depression-with-s8-controls/ [module_atts:td_module:private] => Array ( ) [td_review:protected] => Array ( ) [is_review:protected] => [post_thumb_id:protected] => 29258 [authorType] => )

      PBS-backed esketamine rolls out for depression with S8 controls

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                  [post_date] => 2025-04-30 11:38:14
                  [post_date_gmt] => 2025-04-30 01:38:14
                  [post_content] => 

      Rosa is a 35-year-old professional struggling with persistent sleep disturbances. Despite maintaining a consistent sleep routine, exercising regularly, and avoiding heavy meals before bedtime, she found herself regularly waking during the night.

      The consultation

      [caption id="attachment_27686" align="alignright" width="300"]allergic rhinitis This article is sponsored by Kenvue.[/caption]

      Before providing Rosa a sleep aid such as melatonin supplements, you ask a series of questions to identify potential contributing factors for her condition and to determine if a sleep aid is the best treatment option.

      Key questions to ask

      Medical history:

      • Do you have a history of allergies or asthma?
      • Does anyone in your family have allergies or asthma?

      Duration of symptoms:

      • How long have you noticed symptoms?

      Symptom pattern:

      • Are the sleep disturbances worse at specific times of the year?

      Nasal symptoms:

      • Do you experience nasal congestion or breathing difficulties at night?
      • Have you noticed an increase in sneezing or runny nose lately?
      • Have you noticed any postnasal drip or coughing during the night?

      Sensory Irritation:

      • Do you experience any itching in your nose, eyes or throat?
      • Do your sleep problems coincide with other symptoms such as headaches or sinus pressure?

      Environmental factors:

      • Have there been any recent changes in your living environment that could be contributing to your symptoms?
      • Have you recently introduced new furniture, carpets or other items into your home that might be contributing to your symptoms?
      • Do you have pets in your home? If so, do you notice any worsening of symptoms when they are nearby?
      • Have you noticed any improvement in your sleep when you’re away from your usual environment?

      Timing of symptoms:

      • Are your symptoms worse in the morning or at night?

      Current approaches:

      • How have you been trying to improve your sleep?
      • Have you tried any allergy avoidance strategies such as using air purifiers or keeping pets out of the bedroom?
      • Do you use nasal sprays or other medications for congestion? If so, how often?

      Current medical status and medications:

      • Do you have any other health conditions?
      • Do you currently take any medication?

      The diagnosis

      Rosa reveals that when she wakes, she frequently has a blocked nose and itchy eyes, and she sneezes a lot in the evening before bed. She has suffered from very mild hayfever before but never at this time of year.

      You suspect allergic rhinitis as the root cause. Rosa was surprised. Like many, she had dismissed her nasal congestion as a minor annoyance rather than a significant factor affecting her rest. She didn’t even think one could get hayfever in winter.

      The treatment plan

      You recommend a treatment plan to tackle the root cause of Rosa’s sleep disturbances. With proper treatment, she can manage her symptoms and improve sleep quality. Alongside managing environmental exposure you can recommend an antihistamine like:

      Zyrtec Rapid Acting Allergy Antihistamine and Hayfever Tablets

      Dosage: One tablet daily offers 24-hour protection.

      You can also recommend Rhinocort nasal spray to be used when symptoms become acute.1

      The outcome: restful nights and restored energy

      Within days of following the treatment plan, Rosa noticed a remarkable improvement. Her congestion eased, she wasn’t waking up anymore, and she finally felt refreshed and energised throughout the day.

      By looking beyond the immediate request for sleep aids, the pharmacist was able to identify the true cause of Rosa’s problem and offer a more effective, long-term solution.

      Allergic rhinitis (AR) and sleep disruptions

      Allergic rhinitis (AR), commonly known as hayfever, affects around 19% of Australians.2 Chronic nasalcongestion and other symptoms of allergic rhinitis can significantly impact sleep quality.3 This often results in daytime fatigue, decreased productivity, and impaired cognitive function. Patients may not realise that their persistent tiredness or difficulty concentrating stems from untreated allergies. Zyrtec works fast for hayfever relief and stays strong, day after day offering 24-hour relief from multiple symptoms.

      Zyrtec works fast for hay fever relief and stays strong, day after day.4

      If your patient is struggling with unexplained sleep disturbances, allergies could be the hidden cause.

      With the right management you can help them to reclaim restful sleep and feel their best every day.

      References

      1. Approach to management of allergic rhinitis, [2020; amended July 2024]. In: Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited.
      2. Definition and causes of allergic rhinitis, [2020; amended July 2024]. In: Therapeutic Guidelines.Melbourne: Therapeutic Guidelines Limited.
      3. Wise SK, Damask C, Roland LT, et al. International consensus statement on allergy and rhinology: Allergic rhinitis.
      4. Urdaneta E, et al. Ann Allergy Asthma Immunol 2010;105(5):A121. (Sponsored by Zyrtec.)

      [post_title] => Allergic rhinitis and sleep deprivation: What’s going undetected? [post_excerpt] => Allergic rhinitis (AR), commonly known as hayfever, affects around 19% of Australians. This case study explores how it impacts sleep quality. [post_status] => publish [comment_status] => open [ping_status] => open [post_password] => [post_name] => allergic-rhinitis-and-sleep-deprivation [to_ping] => [pinged] => [post_modified] => 2025-05-05 12:50:52 [post_modified_gmt] => 2025-05-05 02:50:52 [post_content_filtered] => [post_parent] => 0 [guid] => https://www.australianpharmacist.com.au/?p=29210 [menu_order] => 0 [post_type] => post [post_mime_type] => [comment_count] => 0 [filter] => raw ) [title_attribute] => Allergic rhinitis and sleep deprivation: What’s going undetected? [title] => Allergic rhinitis and sleep deprivation: What’s going undetected? [href] => https://www.australianpharmacist.com.au/allergic-rhinitis-and-sleep-deprivation/ [module_atts:td_module:private] => Array ( ) [td_review:protected] => Array ( ) [is_review:protected] => [post_thumb_id:protected] => 29273 [authorType] => )

      Allergic rhinitis and sleep deprivation: What’s going undetected?

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                  [post_date] => 2025-04-22 11:19:25
                  [post_date_gmt] => 2025-04-22 01:19:25
                  [post_content] => 

      Aside from administering medicines by injection, Queensland-based community pharmacist Fiona Watson MPS loves tearing up a Latin dance floor.

      Tell us about your pharmacy career.

      I had a varied early career, moving to North Queensland for a year shortly after I graduated as well as locuming around Australia for a while.

      This gave me a great introduction to community pharmacy and a lot of different experiences – both good and bad. When locuming, you develop a clear idea of the factors that contribute to a well-run pharmacy.

      I then moved to the United Kingdom where I completed a Certificate in Clinical Pharmacy. You can tell how old I am because I was one of the last pharmacists able to register in the UK with only a month under supervision.

      I was a ‘rotational resident pharmacist’, living on-site at the hospital. I covered renal, gastro, cardiology, oncology, aged care, palliative care and surgery wards.

      We worked on call overnight, and could get called upon to help with all sorts of different situations – one of the most interesting being calculating the correct dose for the antidote to antifreeze.

      More recently, I was very fortunate to be given the opportunity to go into partnership with my mum and sister, both pharmacists, as the managing partner at Redland Bay Wholelife Pharmacy and Healthfoods.

      What medicines do you administer by injection?

      About 10 years ago, I became a trained vaccinator administering thousands of vaccines during the COVID-19 pandemic.

      When Queensland allowed pharmacists to expand the range of medicines they could administer, I completed the Medication Administration course, as I believe this is an essential skill for pharmacists to have.

      So many new medications are injectable, and for some patients self-administration just isn’t an option. We were one of the first pharmacies in our area to offer long-acting injectable buprenorphine services, which can be a life-changing option for patients.

      Tell us about your administering injections beyond vaccines.

      The majority of pharmacists I work with at Redland Bay are trained vaccinators and have completed medicines administration courses. When we come across a new medication that requires administration by injection we collate the available information from the manufacturer and ensure everyone has read it. Many companies, such as Novartis with inclisiran (Leqvio), have reps who are happy to provide additional training.

      Once you are comfortable with subcutaneous injections, it’s a matter of familiarising yourself with the different types of devices available. It seemed a logical step for us to provide this service. We have great consult room facilities and it brings variety to our role.

      What role do you see pharmacists playing in cardiovascular care in future?

      The sky is the limit. We’re on the cusp of a fundamental change in the way Australians receive health care and I hope to see pharmacists embrace the opportunities this will bring.

      There’s a workforce crisis and an ageing population, so we need to become more efficient and accessible. If you think about how much the role of a nurse practitioner has changed in the last 10–15 years, you can see where pharmacists have even greater potential. A patient with a diagnosis of heart failure should be able to be titrated to optimum therapy by a pharmacist in a community pharmacy. A patient should have their HbA1c or lipids checked in the pharmacy, with appropriate therapy initiated or adjusted. We should also be actively involved in screening and chronic disease management.

      Pharmacy is an incredibly rewarding and enjoyable career, and now is an especially exciting time to be a pharmacist. There is just so much opportunity. 

      Day in the life of Fiona Watson MPS, Community pharmacist at Redland Bay Wholelife Pharmacy, QLD.

      5.00am

      Hit the gym

      I get up and do a HIIT or Muay Thai class most mornings for positive effects on my mental health. Passionate about preventative health care, I see the long-term effects of patients’ lifestyle choices every day.

      8.00am

      Open the pharmacy Every day is different. At least two pharmacists are rostered on, ensuring we give each patient the time they need while providing a wide range of different services.

      9.00am

      Vaccination service

      Embarking on a cruise in 2 months, a couple in their 60s asks about  COVID-19 vaccines. More than 12 months since their last vaccine they are  happy to be vaccinated on the spot. Not wanting more than one vaccine at a time, we book them in for a follow-up appointment in a month for the shingles vaccination.

      10.00am

      Collaborative care

      A local GP phones about a recently discharged mutual patient who’s not coping well on his new medicines. We spend some time with the patient doing a medicine review and setting up his profile for a dose administration aid.

      1.00pm

      Lunchtime

      It’s important that all staff, especially pharmacists, prioritise their breaks. We all need a little downtime to reset and refresh.

      1.30pm

      Medicines injection

      A regular patient comes in for her second dose of inclisiran (Leqvio) after I administered her first 3 months ago. She is happy with the more convenient option than visiting her GP.

      3.00pm

      Infection control

      In a call from our pharmacy car park, we learn a patient has tested positive for COVID-19 and has an e-script. We dispense and counsel over the phone and then deliver out to their car (with appropriate precautions).

      6.30pm

      OCP continuance

      A stressed young woman, with a 2-week wait for a GP appointment, has run out of her pill. She is relieved when seen by a colleague who prescribes Estelle under the Queensland Hormonal Contraceptive Pilot. I dispense it.

      [post_title] => Injectable medication administration an essential skill [post_excerpt] => Aside from administering medicines by injection, Queensland-based community pharmacist Fiona Watson MPS loves tearing up a Latin dance floor. [post_status] => publish [comment_status] => open [ping_status] => open [post_password] => [post_name] => injectable-medication-administration-an-essential-skill [to_ping] => [pinged] => [post_modified] => 2025-04-30 11:28:21 [post_modified_gmt] => 2025-04-30 01:28:21 [post_content_filtered] => [post_parent] => 0 [guid] => https://www.australianpharmacist.com.au/?p=29196 [menu_order] => 0 [post_type] => post [post_mime_type] => [comment_count] => 0 [filter] => raw ) [title_attribute] => Injectable medication administration an essential skill [title] => Injectable medication administration an essential skill [href] => https://www.australianpharmacist.com.au/injectable-medication-administration-an-essential-skill/ [module_atts:td_module:private] => Array ( ) [td_review:protected] => Array ( ) [is_review:protected] => [post_thumb_id:protected] => 29197 [authorType] => )

      Injectable medication administration an essential skill

  • People
    • td_module_mega_menu Object
      (
          [post] => WP_Post Object
              (
                  [ID] => 29310
                  [post_author] => 3410
                  [post_date] => 2025-05-07 14:26:37
                  [post_date_gmt] => 2025-05-07 04:26:37
                  [post_content] => Merging CAL 18 and CAL I removes duplication and confusion, helping patients receive clearer, more actionable dietary advice.
      
      Australian Pharmacist explores what pharmacists and patients need to know.
      
      What’s changing?
      
      Cautionary advisory label (CAL) 18 and CAL I currently provide dietary advice for specific medicines:
      
      [caption id="attachment_29312" align="aligncenter" width="151"] CAL 18[/caption]
      
      [caption id="attachment_29311" align="aligncenter" width="152"] CAL I[/caption]
      

      Instead of having two labels that relate to avoiding certain foods and juices (CAL 18 and CAL I), there will now be one – an updated CAL 18.

      [caption id="attachment_29313" align="aligncenter" width="189"] Revised CAL 18[/caption]

      What’s the rationale?

      Currently, CAL 18 only warns about grapefruit due to its effect on the bioavailability of certain medicines through the selective inhibition of cytochrome P450 3A4 isoenzymes. But the product information (PI) for new medicines that are substrates for CYP3A4 increasingly mention other fruits (beyond just grapefruit) as interacting with medicines via inhibition of CYP3A4. This includes seville oranges, pomelo, star fruit, bitter melon and pomegranate.  As it stands, the wording of CAL 18 is not broad enough to cover these scenarios. CAL I is currently used to advise patients about fruits and juices that interact with medicines through mechanisms other than inhibition of CYP3A4.  For example, food and drink interactions with non-selective monoamine oxidase inhibitors (MAOIs) and interactions between medicines and fruit juices through mechanisms other than CYP3A4 inhibition (e.g. fexofenadine, which has been found to interact with orange and apple juice).  However, there have been reports of confusion associated with ‘I’ appearing very similar to ‘1’ in the CAL recommendation table. There are also not many medicines CAL I is relevant to at present, so it therefore has limited applicability.  The revised CAL 18, now reading ‘Certain foods and fruit juices should be avoided while being treated with this medicine’, will now cover:
      • interactions with all CYP3A4-inhibiting fruits (for example, grapefruit, Seville orange, pomelo, pomegranate, star fruit) 
      • any newly identified food and juice interactions with medicines – even those that don’t occur by CYP3A4 (e.g. apple and orange juice); and
      • other food and drink interactions with medicines (e.g. foods and drinks rich in tyramine with MAOIs).

      How should pharmacists respond when patients ask which foods and fruit juices should be avoided?

      For those fruits that can inhibit CYP3A4 (e.g. grapefruit, Seville orange, pomelo, star fruit, bitter melon and pomegranate), this can lead to higher drug levels and potential toxicity of relevant CYP3A4 substrates. Pharmacists should advise patients that these fruits should be avoided in any form (e.g. fruit or juice) with these medicines as there is no recommendation on the quantity that can be safely consumed. Beyond CYP3A4 substrates, it becomes more nuanced. For example, atenolol and fexofenadine aren’t metabolised by CYP3A4, yet both can have reduced bioavailability when taken with apple or orange juice – so patients taking these medicines should be advised to avoid these juices. When dispensing MAOIs, pharmacists should counsel patients to avoid tyramine-rich foods such as aged cheeses, cured meats, fermented products, yeast extract products and beer. Other certain foods and drinks must be consumed only in small amounts. MAOIs block the enzyme that normally breaks down tyramine, causing it to accumulate in the bloodstream, which can lead to a hypertensive crisis. Pharmacists should provide an MAOI card to patients, see APF Digital – Counselling advice for monoamine oxidase inhibitors.  It is important that pharmacists check a medicines’ approved PI to confirm the specific foods, fruits and juices that patients should avoid. Appropriate drug interaction resources (e.g. Stockley’s Drug Interactions) should also be used where needed when providing medicine-specific advice.

      When is the change happening?

      The CAL explanatory notes were updated in APF Digital today (7 May 2025). Pharmacists should familiarise themselves with the revised explanatory notes for CAL 18 in the digital Australian Pharmaceutical Formulary and Handbook.

      When will dispensing software be updated with the revised CALs?

      Pharmacists are advised to talk to their dispensing software provider, who can advise when these changes will be implemented.

      When will the new labels arrive?

      It is anticipated printers will commence printing of the new labels during their next print run. Until then, pharmacists should use the existing CAL 18 and CAL I – ensuring patients are equipped with the updated advice, available now in APF Digital which always contains the latest updates. [post_title] => Goodbye CAL I, hello expanded CAL 18 [post_excerpt] => Merging CAL 18 and CAL I removes duplication and confusion, helping patients receive clearer, more actionable dietary advice. [post_status] => publish [comment_status] => open [ping_status] => open [post_password] => [post_name] => goodbye-cal-i-hello-expanded-cal-18 [to_ping] => [pinged] => [post_modified] => 2025-05-07 17:21:44 [post_modified_gmt] => 2025-05-07 07:21:44 [post_content_filtered] => [post_parent] => 0 [guid] => https://www.australianpharmacist.com.au/?p=29310 [menu_order] => 0 [post_type] => post [post_mime_type] => [comment_count] => 0 [filter] => raw ) [title_attribute] => Goodbye CAL I, hello expanded CAL 18 [title] => Goodbye CAL I, hello expanded CAL 18 [href] => https://www.australianpharmacist.com.au/goodbye-cal-i-hello-expanded-cal-18/ [module_atts:td_module:private] => Array ( ) [td_review:protected] => Array ( ) [is_review:protected] => [post_thumb_id:protected] => 29315 [authorType] => )

      Goodbye CAL I, hello expanded CAL 18

      measles
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                  [post_date] => 2025-05-05 14:47:58
                  [post_date_gmt] => 2025-05-05 04:47:58
                  [post_content] => With measles cases climbing across Australia and pharmacies increasingly listed as exposure sites, community pharmacists must be prepared.
      
      
      Earlier this year, a patient who had just returned from Vietnam walked into Advantage Chesterville Pharmacy in Melbourne with a script for antibiotics.
      
      ‘She was wearing a face mask, and when I spoke to her she just said that she had a cough but she wasn't sure what the cough was from,’ said community pharmacist Minh Ngo MPS, who was on duty when the patient came through.
      
      Some time later, the pharmacy received word that the patient was infected with measles.
      
      ‘She either informed the hospital or the GP, but we just got a call from the [Victorian] Department of Health to notify us that we were an exposure case,’ she said.
      
      With measles spreading around Australia at an unprecedented rate, this is a position many pharmacists may soon find themselves in.
      
      Victoria is in the midst of its worst measles outbreak in a decade, with 25 cases recorded so far this year. New South Wales and Western Australia are not far behind, with 21 and 18 cases reported respectively.
      
      Healthcare settings such as pharmacies have been increasingly listed as exposure sites as people seek treatment for the highly infectious and virulent disease.
      
      Australian Pharmacist explores the steps pharmacists should take when confronted with this predicament.
      

      Patient contact tracing

      When a healthcare setting such as a pharmacy becomes a measles exposure site, it is responsible for contact tracing. ‘We had to inform every patient who was in the [pharmacy] at that time that we were informed that the exposure might have happened,’ Ms Ngo said.  This includes asking patients if they have any symptoms. Early symptoms of measles, before the rash appears, include:
      • fever 
      • tiredness 
      • cough 
      • runny nose
      • sore red eyes 
      • malaise.
      ‘We had to inform every patient who was in the [pharmacy] at that time that we were informed that the exposure might have happened.' MINH NGO MPS  

      Post-exposure testing and prophylaxis

      All symptomatic patients who were exposed to measles need to follow specific protocols.  ‘We told them that if they have any symptoms, if they develop any cough or if they have any concerns then go and get tested,’ Ms Ngo said.  Patients who have attended a known exposure site should be offered the Measles, Mumps, and Rubella vaccine within 72 hours of measles exposure to avert infection. In those who are unvaccinated or partially vaccinated, particularly young infants, pregnant people,, or immunocompromised patients – human immunoglobulin (NHIG) administered within six days of exposure may be appropriate. Pharmacists should advise patients with suspected measles to call ahead before visiting their healthcare provider for a PCR test and wear a mask upon leaving home. Suspected cases must remain isolated at home until laboratory testing confirms or excludes measles, avoiding work, school and any public venues. A notification must be made to the relevant department of health when symptoms are present via the patients' local public health unit.

      Important staff protocols

      Fortunately, there were only two members of staff on at the pharmacy including Ms Ngo at the time of the exposure, and neither was infected with measles.
      Local PHUs will identify any staff who may have been exposed to a measles case and assess their immunity status, said a spokesperson from the federal Department of Health and Aged Care. ‘Depending on their vaccination history, some staff members may need to be monitored or excluded from work during the infectious period to minimise the risk of further transmission – this could be for a period up to 18 days,’ the spokesperson said. ‘Post-exposure prophylaxis may be required and will be organised by the local PHU.’ With the number of cases currently floating around, pharmacists should ensure that staff are up to date with their vaccinations in advance All adults born between 1966 and 1992 and who do not have documented evidence of vaccination are eligible for a catch-up vaccine to ensure maximum protection against measles, with the two-dose schedule of the MMR vaccine only being introduced in Australia in 1992. https://twitter.com/VicGovDH/status/1916756251293409486 Should a patient present with a fever and rash, they should be moved out of communal waiting areas and into a dedicated space. If measles is suspected, the patient should be given a disposable, well-sealed mask. [post_title] => Responding to a measles exposure in your pharmacy [post_excerpt] => With measles cases climbing across Australia and pharmacies increasingly listed as exposure sites, community pharmacists must be prepared. [post_status] => publish [comment_status] => open [ping_status] => open [post_password] => [post_name] => responding-to-a-measles-exposure-in-your-pharmacy [to_ping] => [pinged] => [post_modified] => 2025-05-06 10:32:42 [post_modified_gmt] => 2025-05-06 00:32:42 [post_content_filtered] => [post_parent] => 0 [guid] => https://www.australianpharmacist.com.au/?p=29295 [menu_order] => 0 [post_type] => post [post_mime_type] => [comment_count] => 0 [filter] => raw ) [title_attribute] => Responding to a measles exposure in your pharmacy [title] => Responding to a measles exposure in your pharmacy [href] => https://www.australianpharmacist.com.au/responding-to-a-measles-exposure-in-your-pharmacy/ [module_atts:td_module:private] => Array ( ) [td_review:protected] => Array ( ) [is_review:protected] => [post_thumb_id:protected] => 29305 [authorType] => )

      Responding to a measles exposure in your pharmacy

      esketamine
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                  [post_date] => 2025-04-30 11:57:51
                  [post_date_gmt] => 2025-04-30 01:57:51
                  [post_content] => From 1 May, Spravato (esketamine) will be subsidised under the Pharmaceutical Benefits Scheme (PBS) for adults with treatment-resistant depression, intended for use alongside a newly initiated oral antidepressant.
      
      Up to 30,000 Australians are anticipated to access esketamine via the PBS, paying only $7.70 per dose with a pensioner or concession card, or $31.60 per dose for general patients.
      
      [caption id="attachment_29259" align="alignright" width="233"] Professor Malcolm Hopwood[/caption]
      
      Australian Pharmacist spoke with Professor Malcolm Hopwood, Ramsay Health Care Professor of Psychiatry at the University of Melbourne, about the treatment process and how pharmacists will be involved.
      

      How effective is esketamine in managing treatment resistant depression?

      The largest clinical trials on esketamine efficacy found that about 50% of patients who had not responded to two or three antidepressants did respond to esketamine, Prof Hopwood said. ‘If you compare that to trialing one of the usual medicines, the response rate for the third or fourth [medicine] is probably only about 15%,’ he said. ‘So it’s quite a jump up in terms of response rate.’

      Who is eligible to be prescribed esketamine nasal spray?

      Those diagnosed with treatment-resistant depression, defined as major depressive disorder that has not responded sufficiently to at least two different antidepressants, each administered at an adequate dose and duration, for the treatment of the current moderate to severe depressive episode.

      Who is not a good candidate for this treatment?

      Esketamine is currently not indicated for bipolar depression. And caution should be taken for patients with psychotic depression, Prof Hopwood said.  ‘[This is] because ketamine, when used in much higher doses, has psychogenic potential,’ Prof Hopwood said. There is also a precautionary note in the product information around patients with marked hepatic or renal impairment. ‘In terms of drug-drug interactions, it should not be used together with an irreversible monoamine oxidase inhibitor, which these days is only Parnate,’ he said. ‘While not widely used now, it's an important interaction to be aware of.’

      What’s the duration of therapy?

      Esketamine is initially administered twice weekly for the first 4 weeks, Prof Hopwood said. ‘By the end of that 4-week period, we've usually got a sense whether you're a responder or not.’ Treatment usually stops in non-responders, with responders moving to a once-weekly treatment regimen. ‘Eventually, fortnightly treatment for a 6-month maintenance period is what we recommend,’ Prof Hopwood said.

      Is re-treatment recommended?

      Given that depression is a highly recurrent condition, it is likely some patients will relapse post treatment. And re-treatment with esketamine could prove beneficial, Prof Hopwood said. ‘There is some data about re-treatment …  [with] evidence showing that responders do seem to have a good response rate the second time around,’ he said. ‘That will be permitted under this funding scheme.’

      How is esketamine supplied?

      Patients cannot be in possession of the spray until they are in the clinic for administration under supervision, Prof Hopwood said.  ‘Esketamine needs to be administered in an approved treatment center that involves close supervision for side effects such as dissociation and hypertension,’ he said.  Appropriate pharmacist handling of a Schedule 8 medicine is also required. ‘In our facility, we are fortunate to have an on-site pharmacist who dispenses [the medicine] to a nurse, and then the patient self-administers,’ Prof Hopwood said.  ‘But the patient neither brings the medicine to the clinic or takes it away. The intent … is to reduce the risk of diversion.’ Facilities that do not have an on-site pharmacist must establish and demonstrate a connection with a local community pharmacy to qualify as an approved treatment centre.

      Is talk therapy involved in the session?

      Treatment with esketamine does not involve psychotherapy. However, there is a small body of research currently looking at ketamine-facilitated psychotherapy, Prof Hopwood said. ‘We still don't know whether that offers additional benefit for many patients, [but] if esketamine proves an effective treatment for their depression, they may be able to utilise psychotherapy much more effectively – which they might not be able to do when severely depressed.’

      What are the estimated costs of esketamine sessions?

      The estimated cost is $300–$350 per treatment session, Prof Hopwood said. In most clinics, the doctor will see the patient on treatment occasions, but less so as treatment becomes established. ‘If the doctor does visit before the treatment is administered, then they can claim through Medicare as per usual,’ he said. ‘But the nursing and pharmacy [costs] will not be covered.’

      Are patients supposed to disassociate when they take esketamine?

      Dissociation with treatment is frequent, albeit mild and transient for most patients, Prof Hopwood said. ‘For up to half an hour they [may] feel a little dreamy and not unpleasant,’ he said.  Some evidence suggests that mild dissociative effects may be required for the drug to be effective in the treatment of depression, although this is not definitive, Prof Hopwood said. ‘We monitor patients during that time and keep them safe,’ he said. ‘Most of them simply want to lie there and listen to music or just bliss out for a short period of time.’  While there is no reversal agent for esketamine, any periods of distress are typically short lived. ‘We've had a very small number of patients distressed, consistent with the trials,’ Prof Hopwood said. ‘And they've generally responded to quite simple reassurance.’ Patients’ blood pressure is also monitored ‘It's rarely severe enough that intervention is required, but there can be a transient increase, as we've known from the use of ketamine as an anaesthetic,’ he said.

      Where should pharmacists refer interested patients?

      GPs are an important resource for knowing where the available treatment centers are, Prof Hopwood said.  ‘There is a list of those available, and I predict that number may increase over time now that esketamine is funded.’ There are high levels of patient interest in esketamine and psychedelics, Prof Hopwood said. ‘So it's important they receive accurate, quality information that includes realistic expectations about the likelihood of treatment response and what's involved,’ he said. ‘And pharmacists are very well placed to provide that kind of information.’

      What is preferable: esketamine or psychedelics?

      Since 1 July 2023, patients with treatment-resistant depression have legally been allowed to receive treatment with psilocybin and MDMA, under specific conditions.   There is a degree of overlap between the patient populations considered suitable for ketamine and psychedelic therapy, Prof Hopwood said. ‘Most of the current guidance, including from The Royal Australian and New Zealand College of Psychiatrists, would say that psychedelic therapy is still more at a research level,’ he said.  ‘Whereas, esketamine, reflected in the funding, has reached a higher level of evidence at this point.  ‘So I would certainly see it as coming before psychedelic therapy in any hierarchy.’ To find out more about the use of psilocybin for treatment-resistant depression, read Australian Pharmacist's CPD article on the therapeutic potential of psychedelics. [post_title] => PBS-backed esketamine rolls out for depression with S8 controls [post_excerpt] => Esketamine will soon be funded for treatment-resistant depression, requiring pharmacists to adhere to strict supply and handling conditions. [post_status] => publish [comment_status] => open [ping_status] => open [post_password] => [post_name] => pbs-backed-esketamine-rolls-out-for-depression-with-s8-controls [to_ping] => [pinged] => [post_modified] => 2025-04-30 15:17:32 [post_modified_gmt] => 2025-04-30 05:17:32 [post_content_filtered] => [post_parent] => 0 [guid] => https://www.australianpharmacist.com.au/?p=29255 [menu_order] => 0 [post_type] => post [post_mime_type] => [comment_count] => 0 [filter] => raw ) [title_attribute] => PBS-backed esketamine rolls out for depression with S8 controls [title] => PBS-backed esketamine rolls out for depression with S8 controls [href] => https://www.australianpharmacist.com.au/pbs-backed-esketamine-rolls-out-for-depression-with-s8-controls/ [module_atts:td_module:private] => Array ( ) [td_review:protected] => Array ( ) [is_review:protected] => [post_thumb_id:protected] => 29258 [authorType] => )

      PBS-backed esketamine rolls out for depression with S8 controls

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                  [post_date] => 2025-04-30 11:38:14
                  [post_date_gmt] => 2025-04-30 01:38:14
                  [post_content] => 

      Rosa is a 35-year-old professional struggling with persistent sleep disturbances. Despite maintaining a consistent sleep routine, exercising regularly, and avoiding heavy meals before bedtime, she found herself regularly waking during the night.

      The consultation

      [caption id="attachment_27686" align="alignright" width="300"]allergic rhinitis This article is sponsored by Kenvue.[/caption]

      Before providing Rosa a sleep aid such as melatonin supplements, you ask a series of questions to identify potential contributing factors for her condition and to determine if a sleep aid is the best treatment option.

      Key questions to ask

      Medical history:

      • Do you have a history of allergies or asthma?
      • Does anyone in your family have allergies or asthma?

      Duration of symptoms:

      • How long have you noticed symptoms?

      Symptom pattern:

      • Are the sleep disturbances worse at specific times of the year?

      Nasal symptoms:

      • Do you experience nasal congestion or breathing difficulties at night?
      • Have you noticed an increase in sneezing or runny nose lately?
      • Have you noticed any postnasal drip or coughing during the night?

      Sensory Irritation:

      • Do you experience any itching in your nose, eyes or throat?
      • Do your sleep problems coincide with other symptoms such as headaches or sinus pressure?

      Environmental factors:

      • Have there been any recent changes in your living environment that could be contributing to your symptoms?
      • Have you recently introduced new furniture, carpets or other items into your home that might be contributing to your symptoms?
      • Do you have pets in your home? If so, do you notice any worsening of symptoms when they are nearby?
      • Have you noticed any improvement in your sleep when you’re away from your usual environment?

      Timing of symptoms:

      • Are your symptoms worse in the morning or at night?

      Current approaches:

      • How have you been trying to improve your sleep?
      • Have you tried any allergy avoidance strategies such as using air purifiers or keeping pets out of the bedroom?
      • Do you use nasal sprays or other medications for congestion? If so, how often?

      Current medical status and medications:

      • Do you have any other health conditions?
      • Do you currently take any medication?

      The diagnosis

      Rosa reveals that when she wakes, she frequently has a blocked nose and itchy eyes, and she sneezes a lot in the evening before bed. She has suffered from very mild hayfever before but never at this time of year.

      You suspect allergic rhinitis as the root cause. Rosa was surprised. Like many, she had dismissed her nasal congestion as a minor annoyance rather than a significant factor affecting her rest. She didn’t even think one could get hayfever in winter.

      The treatment plan

      You recommend a treatment plan to tackle the root cause of Rosa’s sleep disturbances. With proper treatment, she can manage her symptoms and improve sleep quality. Alongside managing environmental exposure you can recommend an antihistamine like:

      Zyrtec Rapid Acting Allergy Antihistamine and Hayfever Tablets

      Dosage: One tablet daily offers 24-hour protection.

      You can also recommend Rhinocort nasal spray to be used when symptoms become acute.1

      The outcome: restful nights and restored energy

      Within days of following the treatment plan, Rosa noticed a remarkable improvement. Her congestion eased, she wasn’t waking up anymore, and she finally felt refreshed and energised throughout the day.

      By looking beyond the immediate request for sleep aids, the pharmacist was able to identify the true cause of Rosa’s problem and offer a more effective, long-term solution.

      Allergic rhinitis (AR) and sleep disruptions

      Allergic rhinitis (AR), commonly known as hayfever, affects around 19% of Australians.2 Chronic nasalcongestion and other symptoms of allergic rhinitis can significantly impact sleep quality.3 This often results in daytime fatigue, decreased productivity, and impaired cognitive function. Patients may not realise that their persistent tiredness or difficulty concentrating stems from untreated allergies. Zyrtec works fast for hayfever relief and stays strong, day after day offering 24-hour relief from multiple symptoms.

      Zyrtec works fast for hay fever relief and stays strong, day after day.4

      If your patient is struggling with unexplained sleep disturbances, allergies could be the hidden cause.

      With the right management you can help them to reclaim restful sleep and feel their best every day.

      References

      1. Approach to management of allergic rhinitis, [2020; amended July 2024]. In: Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited.
      2. Definition and causes of allergic rhinitis, [2020; amended July 2024]. In: Therapeutic Guidelines.Melbourne: Therapeutic Guidelines Limited.
      3. Wise SK, Damask C, Roland LT, et al. International consensus statement on allergy and rhinology: Allergic rhinitis.
      4. Urdaneta E, et al. Ann Allergy Asthma Immunol 2010;105(5):A121. (Sponsored by Zyrtec.)

      [post_title] => Allergic rhinitis and sleep deprivation: What’s going undetected? [post_excerpt] => Allergic rhinitis (AR), commonly known as hayfever, affects around 19% of Australians. This case study explores how it impacts sleep quality. [post_status] => publish [comment_status] => open [ping_status] => open [post_password] => [post_name] => allergic-rhinitis-and-sleep-deprivation [to_ping] => [pinged] => [post_modified] => 2025-05-05 12:50:52 [post_modified_gmt] => 2025-05-05 02:50:52 [post_content_filtered] => [post_parent] => 0 [guid] => https://www.australianpharmacist.com.au/?p=29210 [menu_order] => 0 [post_type] => post [post_mime_type] => [comment_count] => 0 [filter] => raw ) [title_attribute] => Allergic rhinitis and sleep deprivation: What’s going undetected? [title] => Allergic rhinitis and sleep deprivation: What’s going undetected? [href] => https://www.australianpharmacist.com.au/allergic-rhinitis-and-sleep-deprivation/ [module_atts:td_module:private] => Array ( ) [td_review:protected] => Array ( ) [is_review:protected] => [post_thumb_id:protected] => 29273 [authorType] => )

      Allergic rhinitis and sleep deprivation: What’s going undetected?

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                  [post_date] => 2025-04-22 11:19:25
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                  [post_content] => 

      Aside from administering medicines by injection, Queensland-based community pharmacist Fiona Watson MPS loves tearing up a Latin dance floor.

      Tell us about your pharmacy career.

      I had a varied early career, moving to North Queensland for a year shortly after I graduated as well as locuming around Australia for a while.

      This gave me a great introduction to community pharmacy and a lot of different experiences – both good and bad. When locuming, you develop a clear idea of the factors that contribute to a well-run pharmacy.

      I then moved to the United Kingdom where I completed a Certificate in Clinical Pharmacy. You can tell how old I am because I was one of the last pharmacists able to register in the UK with only a month under supervision.

      I was a ‘rotational resident pharmacist’, living on-site at the hospital. I covered renal, gastro, cardiology, oncology, aged care, palliative care and surgery wards.

      We worked on call overnight, and could get called upon to help with all sorts of different situations – one of the most interesting being calculating the correct dose for the antidote to antifreeze.

      More recently, I was very fortunate to be given the opportunity to go into partnership with my mum and sister, both pharmacists, as the managing partner at Redland Bay Wholelife Pharmacy and Healthfoods.

      What medicines do you administer by injection?

      About 10 years ago, I became a trained vaccinator administering thousands of vaccines during the COVID-19 pandemic.

      When Queensland allowed pharmacists to expand the range of medicines they could administer, I completed the Medication Administration course, as I believe this is an essential skill for pharmacists to have.

      So many new medications are injectable, and for some patients self-administration just isn’t an option. We were one of the first pharmacies in our area to offer long-acting injectable buprenorphine services, which can be a life-changing option for patients.

      Tell us about your administering injections beyond vaccines.

      The majority of pharmacists I work with at Redland Bay are trained vaccinators and have completed medicines administration courses. When we come across a new medication that requires administration by injection we collate the available information from the manufacturer and ensure everyone has read it. Many companies, such as Novartis with inclisiran (Leqvio), have reps who are happy to provide additional training.

      Once you are comfortable with subcutaneous injections, it’s a matter of familiarising yourself with the different types of devices available. It seemed a logical step for us to provide this service. We have great consult room facilities and it brings variety to our role.

      What role do you see pharmacists playing in cardiovascular care in future?

      The sky is the limit. We’re on the cusp of a fundamental change in the way Australians receive health care and I hope to see pharmacists embrace the opportunities this will bring.

      There’s a workforce crisis and an ageing population, so we need to become more efficient and accessible. If you think about how much the role of a nurse practitioner has changed in the last 10–15 years, you can see where pharmacists have even greater potential. A patient with a diagnosis of heart failure should be able to be titrated to optimum therapy by a pharmacist in a community pharmacy. A patient should have their HbA1c or lipids checked in the pharmacy, with appropriate therapy initiated or adjusted. We should also be actively involved in screening and chronic disease management.

      Pharmacy is an incredibly rewarding and enjoyable career, and now is an especially exciting time to be a pharmacist. There is just so much opportunity. 

      Day in the life of Fiona Watson MPS, Community pharmacist at Redland Bay Wholelife Pharmacy, QLD.

      5.00am

      Hit the gym

      I get up and do a HIIT or Muay Thai class most mornings for positive effects on my mental health. Passionate about preventative health care, I see the long-term effects of patients’ lifestyle choices every day.

      8.00am

      Open the pharmacy Every day is different. At least two pharmacists are rostered on, ensuring we give each patient the time they need while providing a wide range of different services.

      9.00am

      Vaccination service

      Embarking on a cruise in 2 months, a couple in their 60s asks about  COVID-19 vaccines. More than 12 months since their last vaccine they are  happy to be vaccinated on the spot. Not wanting more than one vaccine at a time, we book them in for a follow-up appointment in a month for the shingles vaccination.

      10.00am

      Collaborative care

      A local GP phones about a recently discharged mutual patient who’s not coping well on his new medicines. We spend some time with the patient doing a medicine review and setting up his profile for a dose administration aid.

      1.00pm

      Lunchtime

      It’s important that all staff, especially pharmacists, prioritise their breaks. We all need a little downtime to reset and refresh.

      1.30pm

      Medicines injection

      A regular patient comes in for her second dose of inclisiran (Leqvio) after I administered her first 3 months ago. She is happy with the more convenient option than visiting her GP.

      3.00pm

      Infection control

      In a call from our pharmacy car park, we learn a patient has tested positive for COVID-19 and has an e-script. We dispense and counsel over the phone and then deliver out to their car (with appropriate precautions).

      6.30pm

      OCP continuance

      A stressed young woman, with a 2-week wait for a GP appointment, has run out of her pill. She is relieved when seen by a colleague who prescribes Estelle under the Queensland Hormonal Contraceptive Pilot. I dispense it.

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      Injectable medication administration an essential skill

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